Neuropsychological criteria for mild cognitive impairment improves diagnostic precision, biomarker associations, and progression rates

…, EC Edmonds, AJ Jak, LR Clark… - Journal of …, 2014 - content.iospress.com
We compared two methods of diagnosing mild cognitive impairment (MCI): conventional
Petersen/Winblad criteria as operationalized by the Alzheimer’s Disease Neuroimaging …

Susceptibility of the conventional criteria for mild cognitive impairment to false-positive diagnostic errors

EC Edmonds, L Delano-Wood, LR Clark, AJ Jak… - Alzheimer's & …, 2015 - Elsevier
Background We assessed whether mild cognitive impairment (MCI) subtypes could be
empirically derived within the Alzheimer's Disease Neuroimaging Initiative (ADNI) MCI cohort and …

[HTML][HTML] The Wisconsin Registry for Alzheimer's Prevention: a review of findings and current directions

SC Johnson, RL Koscik, EM Jonaitis, LR Clark… - Alzheimer's & Dementia …, 2018 - Elsevier
The Wisconsin Registry for Alzheimer's Prevention is a longitudinal observational cohort
study enriched with persons with a parental history (PH) of probable Alzheimer's disease (AD) …

Specific measures of executive function predict cognitive decline in older adults

LR Clark, DM Schiehser, GH Weissberger… - Journal of the …, 2012 - cambridge.org
Decline in executive function has been noted in the prodromal stage of Alzheimer's disease
(AD) and may presage more global cognitive declines. In this prospective longitudinal study, …

Are empirically-derived subtypes of mild cognitive impairment consistent with conventional subtypes?

LR Clark, L Delano-Wood, DJ Libon… - Journal of the …, 2013 - cambridge.org
Given the importance of identifying dementia prodromes for future treatment efforts, we
examined two methods of diagnosing mild cognitive impairment (MCI) and determined whether …

Amyloid and tau imaging biomarkers explain cognitive decline from late middle-age

…, HA Rowley, CK Stone, KD Mueller, LR Clark… - Brain, 2020 - academic.oup.com
This study investigated differences in retrospective cognitive trajectories between amyloid
and tau PET biomarker stratified groups in initially cognitively unimpaired participants …

Language and task switching in the bilingual brain: Bilinguals are staying, not switching, experts

GH Weissberger, TH Gollan, MW Bondi, LR Clark… - Neuropsychologia, 2015 - Elsevier
Bilinguals' ability to control which language they speak and to switch between languages
may rely on neurocognitive mechanisms shared with non-linguistic task switching. However, …

Interaction of age and APOE genotype on cerebral blood flow at rest

CE Wierenga, LR Clark, SI Dev… - Journal of …, 2013 - content.iospress.com
We investigated the impact of APOE genotype on cerebral blood flow (CBF) in older and
younger adults. Forty cognitively normal older adults (16 ε4 carriers, 24 non-ε4 carriers) and 30 …

[HTML][HTML] Measuring longitudinal cognition: individual tests versus composites

EM Jonaitis, RL Koscik, LR Clark, Y Ma… - Alzheimer's & Dementia …, 2019 - Elsevier
Introduction Longitudinal cohort studies of cognitive aging must confront several sources of
within-person variability in scores. In this article, we compare several neuropsychological …

Verbal fluency and early memory decline: results from the Wisconsin registry for Alzheimer's prevention

…, RL Koscik, A LaRue, LR Clark… - Archives of Clinical …, 2015 - academic.oup.com
This study examined the relationship between phonemic and semantic (category) verbal
fluency and cognitive status in the Wisconsin Registry for Alzheimer’s Prevention (WRAP), a …