The missense of smell: functional variability in the human odorant receptor repertoire
…, A Keller, YR Li, T Zhou, C Trimmer, LL Snyder… - Nature …, 2014 - nature.com
Humans have ∼400 intact odorant receptors, but each individual has a unique set of genetic
variations that lead to variation in olfactory perception. We used a heterologous assay to …
variations that lead to variation in olfactory perception. We used a heterologous assay to …
Genetic variation across the human olfactory receptor repertoire alters odor perception
…, A Keller, NR Murphy, LL Snyder… - Proceedings of the …, 2019 - National Acad Sciences
Humans use a family of more than 400 olfactory receptors (ORs) to detect odors, but there is
currently no model that can predict olfactory perception from receptor activity patterns. …
currently no model that can predict olfactory perception from receptor activity patterns. …
Vector design for liver-specific expression of multiple interfering RNAs that target hepatitis B virus transcripts
LL Snyder, JM Esser, CJ Pachuk, LF Steel - Antiviral research, 2008 - Elsevier
RNA interference (RNAi) is a process that can target intracellular RNAs for degradation in a
highly sequence-specific manner, making it a powerful tool that is being pursued in both …
highly sequence-specific manner, making it a powerful tool that is being pursued in both …
Transport features predict if a molecule is odorous
…, BK Lee, JM Magill, LL Snyder… - Proceedings of the …, 2022 - National Acad Sciences
In studies of vision and audition, stimuli can be chosen to span the visible or audible spectrum;
in olfaction, the axes and boundaries defining the analogous odorous space are unknown…
in olfaction, the axes and boundaries defining the analogous odorous space are unknown…
RNA polymerase III can drive polycistronic expression of functional interfering RNAs designed to resemble microRNAs
LL Snyder, I Ahmed, LF Steel - Nucleic acids research, 2009 - academic.oup.com
In both research and therapeutic applications of RNA interference, it is often advantageous
to silence several targets simultaneously. Toward this end, several groups have developed …
to silence several targets simultaneously. Toward this end, several groups have developed …
High-throughput analysis of mammalian olfactory receptors: Measurement of receptor activation via luciferase activity
C Trimmer, LL Snyder, JD Mainland - JoVE (Journal of Visualized …, 2014 - jove.com
Odorants create unique and overlapping patterns of olfactory receptor activation, allowing a
family of approximately 1,000 murine and 400 human receptors to recognize thousands of …
family of approximately 1,000 murine and 400 human receptors to recognize thousands of …
Drawing the borders of olfactory space
In studies of vision and audition, stimuli can be chosen to span the visible or audible spectrum;
in olfaction, the axes and boundaries defining the analogous odorous space are unknown…
in olfaction, the axes and boundaries defining the analogous odorous space are unknown…
[PDF][PDF] Supplementary Information for Transport Features Predict If a Molecule is Odorous
…, CJ Arayata, RC Gerkin, BK Lee, JM Magill, LL Snyder… - pdfs.semanticscholar.org
Materials and Methods To build models that can predict odorous/odorless status for any
molecule, we generated a large dataset with sufficient chemical diversity to learn generalizable …
molecule, we generated a large dataset with sufficient chemical diversity to learn generalizable …
Daylighting design analysis. Project status report No. 2, 1 March-31 December 1980.[For pre-engineered metal buildings]
WB Hallagan, LL Lindsey, MK Snyder - 1980 - osti.gov
Detailed scale model studies regarding daylighting aspects of the passive/hybrid solar test
building located at Butler Research Center in Grandview, MO are discussed. The product …
building located at Butler Research Center in Grandview, MO are discussed. The product …
Test building instrumentation cooperative agreement: heating/daylighting prototype development. Phase II. Passive and hybrid solar manufactured building project …
LL Lindsey, MK Snyder - 1981 - osti.gov
… Larry Lindsey arid Jack Cooper of PEG arrived at Butler Research Center on the morning
of 25 February. DAS and PET'" were delivered in the early afternoon; visual inspection …
of 25 February. DAS and PET'" were delivered in the early afternoon; visual inspection …