The missense of smell: functional variability in the human odorant receptor repertoire

…, A Keller, YR Li, T Zhou, C Trimmer, LL Snyder… - Nature …, 2014 - nature.com
Humans have ∼400 intact odorant receptors, but each individual has a unique set of genetic
variations that lead to variation in olfactory perception. We used a heterologous assay to …

Genetic variation across the human olfactory receptor repertoire alters odor perception

…, A Keller, NR Murphy, LL Snyder… - Proceedings of the …, 2019 - National Acad Sciences
Humans use a family of more than 400 olfactory receptors (ORs) to detect odors, but there is
currently no model that can predict olfactory perception from receptor activity patterns. …

Vector design for liver-specific expression of multiple interfering RNAs that target hepatitis B virus transcripts

LL Snyder, JM Esser, CJ Pachuk, LF Steel - Antiviral research, 2008 - Elsevier
RNA interference (RNAi) is a process that can target intracellular RNAs for degradation in a
highly sequence-specific manner, making it a powerful tool that is being pursued in both …

Transport features predict if a molecule is odorous

…, BK Lee, JM Magill, LL Snyder… - Proceedings of the …, 2022 - National Acad Sciences
In studies of vision and audition, stimuli can be chosen to span the visible or audible spectrum;
in olfaction, the axes and boundaries defining the analogous odorous space are unknown…

RNA polymerase III can drive polycistronic expression of functional interfering RNAs designed to resemble microRNAs

LL Snyder, I Ahmed, LF Steel - Nucleic acids research, 2009 - academic.oup.com
In both research and therapeutic applications of RNA interference, it is often advantageous
to silence several targets simultaneously. Toward this end, several groups have developed …

High-throughput analysis of mammalian olfactory receptors: Measurement of receptor activation via luciferase activity

C Trimmer, LL Snyder, JD Mainland - JoVE (Journal of Visualized …, 2014 - jove.com
Odorants create unique and overlapping patterns of olfactory receptor activation, allowing a
family of approximately 1,000 murine and 400 human receptors to recognize thousands of …

Drawing the borders of olfactory space

…, CJ Arayata, RC Gerkin, BK Lee, JM Magill, LL Snyder… - bioRxiv, 2020 - biorxiv.org
In studies of vision and audition, stimuli can be chosen to span the visible or audible spectrum;
in olfaction, the axes and boundaries defining the analogous odorous space are unknown…

[PDF][PDF] Supplementary Information for Transport Features Predict If a Molecule is Odorous

…, CJ Arayata, RC Gerkin, BK Lee, JM Magill, LL Snyder… - pdfs.semanticscholar.org
Materials and Methods To build models that can predict odorous/odorless status for any
molecule, we generated a large dataset with sufficient chemical diversity to learn generalizable …

Daylighting design analysis. Project status report No. 2, 1 March-31 December 1980.[For pre-engineered metal buildings]

WB Hallagan, LL Lindsey, MK Snyder - 1980 - osti.gov
Detailed scale model studies regarding daylighting aspects of the passive/hybrid solar test
building located at Butler Research Center in Grandview, MO are discussed. The product …

Test building instrumentation cooperative agreement: heating/daylighting prototype development. Phase II. Passive and hybrid solar manufactured building project …

LL Lindsey, MK Snyder - 1981 - osti.gov
… Larry Lindsey arid Jack Cooper of PEG arrived at Butler Research Center on the morning
of 25 February. DAS and PET'" were delivered in the early afternoon; visual inspection …