Lactate accumulation is a hallmark of solid cancers and is linked to the immune suppressive
phenotypes of tumor-infiltrating immune cells. We report herein that interleukin-4 (IL-4)–…

Glycosylation defects are a hallmark of many nervous system diseases. However, the molecular
and metabolic basis for this pathology is not fully understood. In this study, we found that …

Matrix assisted laser desorption/ionization imaging has greatly improved our understanding
of spatial biology, however a robust bioinformatic pipeline for data analysis is lacking. Here, …

N-linked glycosylation is a complex, co- and post-translational series of events that connects
metabolism to signaling in almost all cells. Metabolic assembly of N-linked glycans spans …

Glycogen dysregulation is a hallmark of aging, and aberrant glycogen drives metabolic
reprogramming and pathogenesis in multiple diseases. However, glycogen heterogeneity in …

N‐linked protein glycosylation in the brain is an understudied facet of glucose utilization that
impacts a myriad of cellular processes including resting membrane potential, axon firing, …

Background & Aims The consumption of sugar and a high-fat diet (HFD) promotes the
development of obesity and metabolic dysfunction. Despite their well-known synergy, the …

Brain glucose metabolism is highly heterogeneous among brain regions and continues
postmortem. In particular, we demonstrate exhaustion of glycogen and glucose and an increase …

MALDI-MSI identifies N-glycan perturbations in prostate tumors compared with benign tissue.
This method can be utilized to predict prostate cancer recurrence and study prostate …

N-glycans and lipids are structural metabolites that play important roles in cellular processes.
Both show unique regional distribution in tissues; therefore, spatial analyses of these …