Parasitic nematodes infect many species of animals throughout the phyla, including humans.
Moreover, nematodes that parasitise plants are a global problem for agriculture. As such, …

C. elegans is sensitive to the majority of anthelmintic drugs that are used against parasitic
worm infections of humans and livestock. This has provided the opportunity to use molecular …

Plant parasitic nematodes infest crops and present a threat to food security worldwide.
Currently available chemical controls eg methyl bromide, organophosphates and carbamates …

Neuropeptides are a diverse class of signalling molecules that are widely employed as
neurotransmitters and neuromodulators in animals, both invertebrate and vertebrate. However, …

Mutations in the human dystrophin gene cause Duchenne muscular dystrophy, a common
neuromuscular disease leading to a progressive necrosis of muscle cells. The etiology of this …

G protein-coupled receptors (GPCRs) are the largest family of genes in animal genomes
and represent more than 2% of genes in humans and C. elegans. These evolutionarily …

There are three major classes of anthelmintics for veterinary use: the benzimidazoles/prebenzimidazoles,
the tetrahydropyrimidines/imidazothiazoles, and the macrocyclic lactones. In …

The cyclo-octadepsipeptide anthelmintic, emodepside, has pleiotropic effects on the behaviour
of the model genetic animal Caenorhabditis elegans: it inhibits locomotion, feeding, egg-…

Neuropeptides are the most diverse class of chemical modulators in nervous systems. They
contribute to extensive modulation of circuit activity and have profound influences on animal …

More than fifty FMRFamide‐like neuropeptides have been identified in nematodes. We
addressed the role of a subset of these in the control of nematode feeding by electrophysiological …