Major depressive disorder (MDD) is a common illness accompanied by considerable
morbidity, mortality, costs, and heightened risk of suicide. We conducted a genome-wide …

Background Early cancer detection could identify tumors at a time when outcomes are
superior and treatment is less morbid. This prospective case-control sub-study (from …

Using the ImmunoChip custom genotyping array, we analyzed 14,498 subjects with multiple
sclerosis and 24,091 healthy controls for 161,311 autosomal variants and identified 135 …

Accurate identification of tumor-derived somatic variants in plasma circulating cell-free DNA
(cfDNA) requires understanding of the various biological compartments contributing to the …

To examine the role of T cell receptor (TCR) in γδ T cells in adaptive immunity, a macaque
model was used to follow Vγ2Vδ2 + T cell responses to mycobacterial infections. These …

Single-nucleotide polymorphisms (SNPs) are the most common type of genetic variation in
man. Genes containing one or more SNPs can give rise to two or more allelic forms of mRNAs…

Background: Stroke is a leading cause of adult disability that can severely compromise the
quality of life of patients, yet no effective medication currently exists to accelerate rehabilitation…

The role of CD8 T cells in anti-tuberculosis immunity in humans remains unknown, and
studies of CD8 T cell–mediated protection against tuberculosis in mice have yielded …

Using genome-wide genotypes, we characterized the genetic structure of 103,006
participants in the Kaiser Permanente Northern California multi-ethnic Genetic Epidemiology …

Importance Most previous genome-wide association studies (GWAS) of depression have used
data from individuals of European descent. This limits the understanding of the underlying …