Background Until now, polymyxin resistance has involved chromosomal mutations but has
never been reported via horizontal gene transfer. During a routine surveillance project on …

Gene Ontology (GO), the de facto standard in gene functionality description, is used widely
in functional annotation and enrichment analysis. Here, we introduce agriGO, an integrated …

Cetuximab is a monoclonal antibody that targets the human epidermal growth factor receptor
(EGFR). Although approved for use in EGFR-overexpressing advanced colorectal cancer, …

Bortezomib, a proteasome inhibitor, shows substantial anti-tumor activity in a variety of
tumor cell lines, is in phase I, II, and III clinical trials and has recently been approved for the …

Rationale: Incident pulmonary arterial hypertension was underrepresented in most pulmonary
hypertension registries and may have a different disease profile to prevalent disease. …

Severe acute respiratory syndrome coronavirus (SARS-CoV) is the pathogen of SARS,
which caused a global panic in 2003. We describe here the screening of Chinese herbal …

MicroRNAs (miRNA) are ∼21 nucleotide-long non-coding small RNAs, which function as
post-transcriptional regulators in eukaryotes. miRNAs play essential roles in regulating plant …

Multiple myeloma (MM) is an incurable hematological malignancy. Chimeric antigen receptor
(CAR)-expressing T cells have been demonstrated successfully in the clinic to treat B-…

Both activated and resting CD4 + T cells in mucosal tissues play important roles in the earliest
phases of infection after sexual transmission of HIV-1, a process that is inefficient. HIV-1 …

Alzheimer’s disease (AD) is the most common dementia in the elderly. Treatment for AD is
still a difficult task in clinic. AD is associated with abnormal gut microbiota. However, little is …