Embryonic development is tightly controlled. The clustered genes of the Hox family of
homeobox proteins play an important part in regulating this development and also proliferation. …

During coordinated development of two neighboring organs from the same germ layer, how
precursors of one organ resist the inductive signals of the other to avoid being misinduced to …

Mechanisms underlying cell-type-specific response to morphogens or signaling molecules
during embryonic development are poorly understood. To learn how response to the liver-…

RNA fluorescence in situ hybridization (FISH) and antibody staining/immunofluorescence (IF)
are widely used to detect distributions of mRNAs and proteins. Here we describe a …

Background & Aims The liver has high regenerative capacity, but it is not clear whether most
biliary cells (particularly larger cholangiocytes) transdifferentiate into hepatocytes in …

In the mouse embryo, the aorta-gonad-mesonephros (AGM) region is considered to be the
sole location for intraembryonic emergence of hematopoietic stem cells (HSCs). Here we …

Graphene possesses unique physical and chemical properties, which have inspired a wide
range of potential biomedical applications. However, little is known about the adverse effects …

Hemorrhagic stroke and brain microbleeds are caused by cerebrovascular ruptures. Fast
repair of such ruptures is the most promising therapeutic approach. Due to a lack of high-…

Congenital scoliosis (CS) is a complex genetic disorder characterized by vertebral malformations.
The precise etiology of CS is not fully defined. Here, we identify that mutation in dual …

The mammalian target of rapamycin (mTOR), is a serine/threonine protein kinase and belongs
to the phosphatidylinositol 3-kinase (PI3K)-related kinase (PIKK) family. mTOR interacts …