The prevailing view that the evolution of cells in a tumor is driven by Darwinian selection
has never been rigorously tested. Because selection greatly affects the level of intratumor …

Acute leukemia characterized by chromosomal rearrangements requires additional molecular
disruptions to develop into full-blown malignancy 1 , 2 , yet the cooperative mechanisms …

We present the analysis of the evolution of tumors in a case of hepatocellular carcinoma. This
case is particularly informative about cancer growth dynamics and the underlying driving …

Aggressive NK-cell leukemia (ANKL) is a rare form of NK cell neoplasm that is more prevalent
among people from Asia and Central and South America. Patients usually die within days …

Background Genomic DNA reference materials are widely recognized as essential for ensuring
data quality in omics research. However, relying solely on reference datasets to evaluate …

Pituitary null cell adenoma is a challenging clinical condition, and its pathogenesis remains
to be elucidated. We performed this study to determine the roles of C5orf66-AS1, NORAD, …

Genome variant detection is a challenge task in cancer genome analysis. Current software
for variant detection is very time-consuming and in the same time not accurate enough to …

Abstract: The Huachanggou gold deposit of Shaanxi Province occurs in the submarine basic
volcanic effusive spillite. Based on field geological work in the Huachanggou gold deposit, …

Aims: Primary hepatic neuroendocrine neoplasms (phNENs) is a rare and poorly
understood type of primary liver cancer. We aimed to perform a comprehensive molecular …

Germline and somatic variant detection from human and cancer whole-genome sequencing
data is a challenge task for genome-wide association study and cancer genomics in …