[HTML][HTML] Research priorities for an HIV cure: international AIDS society global scientific strategy 2021

…, J Sugarman, CT Tiemessen, L Vandekerckhove… - Nature medicine, 2021 - nature.com
Despite the success of antiretroviral therapy (ART) for people living with HIV, lifelong treatment
is required and there is no cure. HIV can integrate in the host genome and persist for the …

[HTML][HTML] Risk of HIV transmission through condomless sex in serodifferent gay couples with the HIV-positive partner taking suppressive antiretroviral therapy …

…, S O'Dea, S De Wit, C Necsoi, L Vandekerckhove… - The Lancet, 2019 - thelancet.com
Background The level of evidence for HIV transmission risk through condomless sex in
serodifferent gay couples with the HIV-positive partner taking virally suppressive antiretroviral …

[HTML][HTML] On the whereabouts of SARS-CoV-2 in the human body: A systematic review

…, W Snippenberg, S Gerlo, L Vandekerckhove - PLoS …, 2020 - journals.plos.org
Since SARS-CoV-2 appeared in the human population, the scientific community has scrambled
to gather as much information as possible to find good strategies for the containment …

[PDF][PDF] HIV rebound is predominantly fueled by genetically identical viral expansions from diverse reservoirs

…, P Lemey, S Palmer, L Vandekerckhove - Cell host & …, 2019 - cell.com
Viral rebound upon stopping combined antiretroviral therapy poses a major barrier toward
an HIV cure. Cellular and anatomical sources responsible for reinitiating viral replication …

[HTML][HTML] Monkeypox virus infection in humans across 16 countries—April–June 2022

…, V Apea, C Boesecke, L Vandekerckhove… - … England Journal of …, 2022 - Mass Medical Soc
Background Before April 2022, monkeypox virus infection in humans was seldom reported
outside African regions where it is endemic. Currently, cases are occurring worldwide. …

[HTML][HTML] In-depth virological and immunological characterization of HIV-1 cure after CCR5Δ32/Δ32 allogeneic hematopoietic stem cell transplantation

…, J Hauber, E Heger, J De Clercq, L Vandekerckhove… - Nature medicine, 2023 - nature.com
Despite scientific evidence originating from two patients published to date that CCR5Δ32/Δ32
hematopoietic stem cell transplantation (HSCT) can cure human immunodeficiency virus …

Dolutegravir plus lamivudine versus dolutegravir plus tenofovir disoproxil fumarate and emtricitabine in antiretroviral-naive adults with HIV-1 infection (GEMINI-1 and …

…, P Lacor, B Vandercam, L Vandekerckhove… - The Lancet, 2019 - thelancet.com
Background Effective two-drug regimens could decrease long-term drug exposure and toxicity
with HIV-1 antiretroviral therapy (ART). We therefore aimed to evaluate the efficacy and …

[HTML][HTML] Integrase Mutants Defective for Interaction with LEDGF/p75 Are Impairedin Chromosome Tethering and HIV-1Replication

…, B Van Maele, D Tempé, L Vandekerckhove… - Journal of Biological …, 2005 - ASBMB
The insertion of a DNA copy of its RNA genome into a chromosome of the hostcell is mediated
by the viral integrase with the help of mostlyuncharacterized cellular cofactors. We have …

[HTML][HTML] Reference gene validation for RT-qPCR, a note on different available software packages

…, M Bergmann, R Brehm, S Kliesch, L Vandekerckhove… - PloS one, 2015 - journals.plos.org
Background An appropriate normalization strategy is crucial for data analysis from real time
reverse transcription polymerase chain reactions (RT-qPCR). It is widely supported to …

[HTML][HTML] Effect of anti-interleukin drugs in patients with COVID-19 and signs of cytokine release syndrome (COV-AID): a factorial, randomised, controlled trial

…, L Naesens, F Haerynck, L Vandekerckhove… - The Lancet …, 2021 - thelancet.com
Background Infections with SARS-CoV-2 continue to cause significant morbidity and mortality.
Interleukin (IL)-1 and IL-6 blockade have been proposed as therapeutic strategies in …