Autosomal Recessive Spastic Ataxia of Charlevoix-Saguenay (ARSACS) is caused by
mutations in the gene SACS, encoding the 520 kDa protein sacsin. Although sacsin’s …

The neurodegenerative disease autosomal recessive spastic ataxia of Charlevoix Saguenay
(ARSACS) is caused by loss of function of sacsin, a modular protein that is required for …

Autosomal recessive spastic ataxia of Charlevoix-Saguenay (ARSACS) is a childhood-onset
cerebellar ataxia caused by mutations in SACS, which encodes the protein sacsin. Cellular …

GATA3 is as a lineage-specific transcription factor that drives the differentiation of CD4 + T
helper 2 (Th2) cells, but is also involved in a variety of processes such as immune regulation, …

Spinocerebellar ataxia type 8 (SCA8), a dominantly inherited neurodegenerative disorder
caused by a CTG•CAG expansion, is unusual because most individuals that carry the mutation …

Primary cilia are sensory organelles involved in regulation of cellular signaling. Cilia loss is
frequently observed in tumors; yet, the responsible mechanisms and consequences for …

The ataxia-linked protein sacsin has three regions of partial homology to Hsp90’s N-terminal
ATP binding domain. Although a crystal structure for this Hsp90-like domain has been …

Autosomal recessive spastic ataxia of Charlevoix-Saguenay (ARSACS) is caused by
mutations in SACS, which manifest as a childhood-onset cerebellar ataxia. Cellular ARSACS …

Introductory paragraph GATA binding protein 3 (GATA3) has traditionally been regarded as
a lineage-specific transcription factor that drives the differentiation of CD4 + T helper (Th) 2 …

… Antenna (LISA) relies on the combined use of two LISA channels, … of the second round of
the Mock LISA Data Challenges. For the … for more realistic studies of LISA’s performance and …