User profiles for Lisa M. Arendt

Lisa Arendt

Associate Professor, University of Wisconsin-Madison
Verified email at wisc.edu
Cited by 3982

Normal and neoplastic nonstem cells can spontaneously convert to a stem-like state

…, Y Su, K Polyak, LM Arendt… - Proceedings of the …, 2011 - National Acad Sciences
Current models of stem cell biology assume that normal and neoplastic stem cells reside at
the apices of hierarchies and differentiate into nonstem progeny in a unidirectional manner. …

Defining the cellular precursors to human breast cancer

PJ Keller, LM Arendt, A Skibinski… - Proceedings of the …, 2012 - National Acad Sciences
Human breast cancers are broadly classified based on their gene-expression profiles into
luminal- and basal-type tumors. These two major tumor subtypes express markers …

Obesity promotes breast cancer by CCL2-mediated macrophage recruitment and angiogenesis

LM Arendt, J McCready, PJ Keller, DD Baker, SP Naber… - Cancer research, 2013 - AACR
Obesity is one of the most important preventable causes of cancer and the most significant
risk factor for breast cancer in postmenopausal women. Compared with lean women, obese …

[HTML][HTML] Mapping the cellular and molecular heterogeneity of normal and malignant breast tissues and cultured cell lines

PJ Keller, AF Lin, LM Arendt, I Klebba, AD Jones… - Breast cancer …, 2010 - Springer
Introduction Normal and neoplastic breast tissues are comprised of heterogeneous populations
of epithelial cells exhibiting various degrees of maturation and differentiation. While …

Prolactin induces ERα-positive and ERα-negative mammary cancer in transgenic mice

TA Rose-Hellekant, LM Arendt, MD Schroeder… - Oncogene, 2003 - nature.com
The role of prolactin in human breast cancer has been controversial. However, it is now
apparent that human mammary epithelial cells can synthesize prolactin endogenously, …

Stroma in breast development and disease

LM Arendt, JA Rudnick, PJ Keller… - Seminars in cell & …, 2010 - Elsevier
It is increasingly apparent that normal and malignant breast tissues require complex local
and systemic stromal interactions for development and progression. During development, …

Form and function: how estrogen and progesterone regulate the mammary epithelial hierarchy

LM Arendt, C Kuperwasser - Journal of mammary gland biology and …, 2015 - Springer
The mammary gland undergoes dramatic post-natal growth beginning at puberty, followed
by full development occurring during pregnancy and lactation. Following lactation, the alveoli …

[HTML][HTML] Growth of human breast tissues from patient cells in 3D hydrogel scaffolds

…, DH Miller, A Breggia, KC Spencer, LM Arendt… - Breast Cancer …, 2016 - Springer
Background Three-dimensional (3D) cultures have proven invaluable for expanding human
tissues for basic research and clinical applications. In both contexts, 3D cultures are most …

Automated quantification of three-dimensional organization of fiber-like structures in biological tissues

…, A Sundarakrishnan, CKH Mingalone, LM Arendt… - Biomaterials, 2017 - Elsevier
Fiber-like structures are prevalent in biological tissues, yet quantitative approaches to assess
their three-dimensional (3D) organization are lacking. We develop 3D directional variance, …

[HTML][HTML] Prolactin-induced mouse mammary carcinomas model estrogen resistant luminal breast cancer

LM Arendt, DE Rugowski, TA Grafwallner-Huseth… - Breast Cancer …, 2011 - Springer
Introduction Tumors that express estrogen receptor alpha (ERα+) comprise 75% of breast
cancers in women. While treatments directed against this receptor have successfully lowered …