ALZHEIMER'S disease (AD) is the most common cause of progressive intellectual failure in
aged humans. AD brains contain numerous amyloid plaques surrounded by dystrophic …

PROGRESSIVE cerebral deposition of the 39–43-amino-acid amy-loid β-protein (Aβ) is an
invariant feature of Alzheimer's disease which precedes symptoms of dementia by years or …

Amyloid plaques are a neuropathological hallmark of Alzheimer's disease (AD), but their
relationship to neurodegeneration and dementia remains controversial. In contrast, there is a …

Proteolytic processing of the amyloid precursor protein (APP) generates amyloid β (Aβ)
peptide, which is thought to be causal for the pathology and subsequent cognitive decline in …

Autosomal dominant forms of familial Alzheimer’s disease (FAD) are associated with
increased production of the amyloid β peptide, Aβ42, which is derived from the amyloid protein …

Alzheimer’s disease (AD) is a neurodegenerative disorder characterized by accumulation of
amyloid plaques and neurofibrillary tangles in the brain. The major components of plaque, β…

Mice that overexpress the human mutant amyloid precursor protein (hAPP) show learning
deficits, but the apparent lack of a relationship between these deficits and the progressive β-…

Abnormal accumulation of the amyloid-β peptide (Aβ) in the brain appears crucial to pathogenesis
in all forms of Alzheimer disease (AD), but the underlying mechanisms in the sporadic …

Dementia with Lewy bodies (DLB) and Parkinson's Disease (PD) are common causes of
motor and cognitive deficits and are associated with the abnormal accumulation of alpha-…

Deposition of amyloid-β peptide in the central nervous system is a hallmark of Alzheimer's
disease and a possible cause of neurodegeneration 1 , 2 , 3 . The factors that initiate or …