Representation of capsaicin-evoked urge-to-cough in the human brain using functional magnetic resonance imaging

SB Mazzone, L McLennan, AE McGovern… - American journal of …, 2007 - atsjournals.org
Rationale: Coughing in humans is typically preceded by a desire (or urge) to cough. The
neural circuitry involved in sensing airway irritation and generating the urge-to-cough in …

[HTML][HTML] Clinical validation of a next-generation sequencing-based multi-cancer early detection “liquid biopsy” blood test in over 1,000 dogs using an independent …

A Flory, KM Kruglyak, JA Tynan, LM McLennan… - PLoS …, 2022 - journals.plos.org
Cancer is the leading cause of death in dogs, yet there are no established screening
paradigms for early detection. Liquid biopsy methods that interrogate cancer-derived genomic …

[HTML][HTML] Age at cancer diagnosis by breed, weight, sex, and cancer type in a cohort of more than 3,000 dogs: Determining the optimal age to initiate cancer screening …

…, MC Rosentel, L DiMarzio, LM McLennan… - PLoS …, 2023 - journals.plos.org
The goal of cancer screening is to detect disease at an early stage when treatment may be
more effective. Cancer screening in dogs has relied upon annual physical examinations and …

[HTML][HTML] Blood-based liquid biopsy for comprehensive cancer genomic profiling using next-generation sequencing: an emerging paradigm for non-invasive cancer …

KM Kruglyak, J Chibuk, L McLennan… - Frontiers in Veterinary …, 2021 - frontiersin.org
This proof-of-concept study demonstrates that blood-based liquid biopsy using next
generation sequencing of cell-free DNA can non-invasively detect multiple classes of genomic …

Next-generation sequencing-based liquid biopsy may be used for detection of residual disease and cancer recurrence monitoring in dogs

…, CA Ruiz-Perez, LM McLennan… - American Journal of …, 2024 - Am Vet Med Assoc
OBJECTIVE The purpose of this study was to evaluate the performance of a next-generation
sequencing-based liquid biopsy test for cancer monitoring in dogs. SAMPLES Pre- and …

Cancer detection in clinical practice and using blood‐based liquid biopsy: A retrospective audit of over 350 dogs

A Flory, L McLennan, B Peet, M Kroll… - Journal of veterinary …, 2023 - Wiley Online Library
Background Guidelines‐driven screening protocols for early cancer detection in dogs are
lacking, and cancer often is detected at advanced stages. Hypothesis/Objectives To examine …

Using metaphors to assess anticipatory perceptions of personal death

J McLennan, CA Stewart, AC Pollard… - The Journal of …, 1997 - Taylor & Francis
The Revised Death Fantasy Scale (RDFS) is an 18-item measure based on metaphors of
personal death. It was constructed to assess psychological aspects of contemplating personal …

Age at cancer diagnosis by breed, weight, sex, and cancer type in a cohort of over 3,000 dogs: determining the optimal age to initiate cancer screening in canine …

…, G Brandstetter, MC Rosentel, LM McLennan… - Biorxiv, 2022 - biorxiv.org
The goal of cancer screening is to detect disease at an early stage when treatment may be
more effective. Until recently, cancer screening in dogs has relied upon annual physical …

[HTML][HTML] Clinical validation of a blood-based liquid biopsy test integrating cell-free DNA quantification and next-generation sequencing for cancer screening in dogs

…, AL O'Kell, BK Flesner, LM McLennan… - Journal of the …, 2024 - Am Vet Med Assoc
OBJECTIVE To validate the performance of a novel, integrated test for canine cancer
screening that combines cell-free DNA quantification with next-generation sequencing …

[HTML][HTML] Detection of Age-Related Somatic Alterations in Canine Blood Using Next-Generation Sequencing-Based Liquid Biopsy: An Analysis of over 4800 Dogs

…, MC Rosentel, LK Wong, LM McLennan… - Veterinary …, 2023 - mdpi.com
Simple Summary In humans there is a biological phenomenon known as CHIP (clonal
hematopoiesis of indeterminate potential) in which somatic (acquired) mutations cause blood …