The COVID-19 pandemic, caused by the novel coronavirus SARS-CoV-2, creates an urgent
need for identifying molecular mechanisms that mediate viral entry, propagation, and tissue …

Organ- and body-scale cell atlases have the potential to transform our understanding of
human biology. To capture the variability present in the population, these atlases must include …

Single-cell technologies have transformed our understanding of human tissues. Yet, studies
typically capture only a limited number of donors and disagree on cell type definitions. …

Angiotensin-converting enzyme 2 (ACE2) and accessory proteases (TMPRSS2 and CTSL)
are needed for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) cellular entry…

Aberrant inflammation in the CNS has been implicated as a major player in the pathogenesis
of human neurodegenerative disease. We developed a new approach to derive microglia …

Most adult carcinomas develop from noninvasive precursor lesions, a progression that is
supported by genetic analysis. However, the evolutionary and genetic relationships among co-…

The Human Cell Atlas (HCA) consortium aims to establish an atlas of all organs in the healthy
human body at single-cell resolution to increase our understanding of basic biological …

Recent whole genome melanoma sequencing studies have identified recurrent mutations in
the gene encoding the catalytic subunit of serine/threonine phosphatase 6 (PPP6C/PP6C). …

With progressive digitalization of healthcare systems worldwide, large-scale collection of
electronic health records (EHRs) has become commonplace. However, an extensible …

Single-cell genomics is now producing an ever-increasing amount of datasets that, when
integrated, could provide large-scale reference atlases of tissue in health and disease. Such …