Rapid large-scale testing is essential for controlling the ongoing pandemic of severe acute
respiratory syndrome coronavirus 2 (SARS-CoV-2). The standard diagnostic pipeline for …

Coronavirus replication is associated with the remodeling of cellular membranes, resulting
in the formation of double-membrane vesicles (DMVs). A DMV-spanning pore was identified …

Regulation of viral RNA biogenesis is fundamental to productive SARS-CoV-2 infection. To
characterize host RNA-binding proteins (RBPs) involved in this process, we biochemically …

Combinations of direct-acting antivirals are needed to minimize drug resistance mutations
and stably suppress replication of RNA viruses. Currently, there are limited therapeutic …

Highlights • Whole-cell and on-lamellae cryo-ET for structural studies of viral infection. •
Inactivation protocols for improved structural preservation and biosafety. • VLP and replicon …

Coronavirus replication is associated with the remodeling of cellular membranes resulting
in the formation of double-membrane vesicles (DMVs). Recently, a pore spanning DMV was …

Diseases, Heidelberg University, Heidelberg, Germany, 6Glycores 2000 Srl, Milan, Italy,
7Department of Microbiology and Virology, Spedali Civili, Brescia, Italy, 8Faculty of Biosciences, …

In vivo, HIV-1 replicates within 3D tissues, yet the impact of tissue-like environments on viral
spread is largely unknown. Our previous research identified that synthetic 3D environments …

Background & Aims Serum concentrations of miR‐122 were proposed as a marker for various
inflammatory diseases, but the mechanisms driving alterations in miR‐122 serum levels …

Combinations of direct-acting antivirals are needed to minimize drug-resistance mutations
and stably suppress replication of RNA viruses. Currently, there are limited therapeutic …