User profiles for Liviu Aron
 | Liviu AronAlice Weiner Senior Research Fellow in Genetics - Harvard University Verified email at hms.harvard.edu Cited by 3537 |
The DNA damage response induces inflammation and senescence by inhibiting autophagy of GATA4
INTRODUCTION Cellular senescence is a program of arrested proliferation and altered
gene expression triggered by many stresses. Although it is a potent tumor-suppressive …
gene expression triggered by many stresses. Although it is a potent tumor-suppressive …
REST and stress resistance in ageing and Alzheimer's disease
Human neurons are functional over an entire lifetime, yet the mechanisms that preserve
function and protect against neurodegeneration during ageing are unknown. Here we show that …
function and protect against neurodegeneration during ageing are unknown. Here we show that …
[PDF][PDF] TBK1 suppresses RIPK1-driven apoptosis and inflammation during development and in aging
Aging is a major risk factor for both genetic and sporadic neurodegenerative disorders.
However, it is unclear how aging interacts with genetic predispositions to promote …
However, it is unclear how aging interacts with genetic predispositions to promote …
Three circadian clock genes Per2, Arntl, and Npas2 contribute to winter depression
…, J Frank, C Johansson, M Depner, L Aron… - Annals of …, 2007 - Taylor & Francis
Background. Multiple lines of evidence suggest that the circadian clock contributes to the
pathogenesis of winter depression or seasonal affective disorder (SAD). We hypothesized that …
pathogenesis of winter depression or seasonal affective disorder (SAD). We hypothesized that …
[HTML][HTML] Absence of Ret signaling in mice causes progressive and late degeneration of the nigrostriatal system
ER Kramer, L Aron, GMJ Ramakers, S Seitz… - PLoS …, 2007 - journals.plos.org
Support of ageing neurons by endogenous neurotrophic factors such as glial cell line–derived
neurotrophic factor (GDNF) and brain-derived neurotrophic factor (BDNF) may determine …
neurotrophic factor (GDNF) and brain-derived neurotrophic factor (BDNF) may determine …
Regulation of lifespan by neural excitation and REST
The mechanisms that extend lifespan in humans are poorly understood. Here we show that
extended longevity in humans is associated with a distinct transcriptome signature in the …
extended longevity in humans is associated with a distinct transcriptome signature in the …
Repairing the parkinsonian brain with neurotrophic factors
No therapy exists to slow down or prevent Parkinson's disease (PD), a debilitating
neurodegenerative disorder. Neurotrophic factors (NTFs) emerged as promising disease-modifying …
neurodegenerative disorder. Neurotrophic factors (NTFs) emerged as promising disease-modifying …
The adaptive aging brain
The aging brain is shaped by many structural and functional alterations. Recent cross-disciplinary
efforts have uncovered powerful and integrated adaptive mechanisms that promote …
efforts have uncovered powerful and integrated adaptive mechanisms that promote …
Pitx3 is a critical mediator of GDNF-induced BDNF expression in nigrostriatal dopaminergic neurons
Pitx3 is a critical homeodomain transcription factor for the proper development and survival
of mesodiencephalic dopaminergic (mdDA) neurons in mammals. Several variants of this …
of mesodiencephalic dopaminergic (mdDA) neurons in mammals. Several variants of this …
[HTML][HTML] Inactivation of VCP/ter94 Suppresses Retinal Pathology Caused by Misfolded Rhodopsin in Drosophila
The most common Rhodopsin (Rh) mutation associated with autosomal dominant retinitis
pigmentosa (ADRP) in North America is the substitution of proline 23 by histidine (Rh P23H ). …
pigmentosa (ADRP) in North America is the substitution of proline 23 by histidine (Rh P23H ). …