Understanding metabolism is indispensable in unraveling the mechanistic basis of many
physiological and pathological processes. However, in situ metabolic imaging tools are still …

All molecules consist of chemical bonds, and much can be learned from mapping the
spatiotemporal dynamics of these bonds. Since its invention a decade ago, stimulated Raman …

Water is arguably the most common and yet least understood material on Earth. Indeed, the
biophysical behavior of water in crowded intracellular milieu is a long-debated issue. …

Mapping the localization of multiple proteins in their native three-dimensional (3D) context
would be useful across many areas of biomedicine, but multiplexed fluorescence imaging has …

Optical microscopy has served biomedical research for decades due to its high temporal and
spatial resolutions. Among various optical imaging techniques, fluorescence imaging offers …

The ability to visualize directly a large number of distinct molecular species inside cells is
increasingly essential for understanding complex systems and processes. Even though …

Powerful optical tools have revolutionized science and technology. The prevalent fluorescence
detection offers superb sensitivity down to single molecules but lacks sufficient chemical …

The effect of infectious bursal disease virus (IBDV) infection on cellular protein expression is
essential for viral pathogenesis. To characterize the cellular response to IBDV infection, the …

Stimulated Raman scattering (SRS) microscopy is an emerging technology that provides
high chemical specificity for endogenous biomolecules and can circumvent common …

Multiplexed optical imaging provides holistic visualization on a vast number of molecular
targets, which has become increasingly essential for understanding complex biological …