[PDF][PDF] PARP inhibition elicits STING-dependent antitumor immunity in Brca1-deficient ovarian cancer
PARP inhibitors have shown promising clinical activities for patients with BRCA mutations
and are changing the landscape of ovarian cancer treatment. However, the therapeutic …
and are changing the landscape of ovarian cancer treatment. However, the therapeutic …
[HTML][HTML] CellProfiler 3.0: Next-generation image processing for biology
CellProfiler has enabled the scientific research community to create flexible, modular image
analysis pipelines since its release in 2005. Here, we describe CellProfiler 3.0, a new …
analysis pipelines since its release in 2005. Here, we describe CellProfiler 3.0, a new …
[PDF][PDF] Vimentin intermediate filaments template microtubule networks to enhance persistence in cell polarity and directed migration
Z Gan, L Ding, CJ Burckhardt, J Lowery, A Zaritsky… - Cell systems, 2016 - cell.com
Increased expression of vimentin intermediate filaments (VIFs) enhances directed cell
migration, but the mechanism behind VIFs' effect on motility is not understood. VIFs interact with …
migration, but the mechanism behind VIFs' effect on motility is not understood. VIFs interact with …
[HTML][HTML] LncRNA MALAT1 enhances oncogenic activities of EZH2 in castration-resistant prostate cancer
The Polycomb protein enhancer of zeste homolog 2 (EZH2) is frequently overexpressed in
advanced human prostate cancer (PCa), especially in lethal castration-resistant prostate …
advanced human prostate cancer (PCa), especially in lethal castration-resistant prostate …
Clonal production and organization of inhibitory interneurons in the neocortex
…, S Chen, Z Han, CH Lu, X Tan, XJ Zhang, L Ding… - Science, 2011 - science.org
The neocortex contains excitatory neurons and inhibitory interneurons. Clones of neocortical
excitatory neurons originating from the same progenitor cell are spatially organized and …
excitatory neurons originating from the same progenitor cell are spatially organized and …
BRCA1 is a negative modulator of the PRC2 complex
L Wang, X Zeng, S Chen, L Ding, J Zhong… - The EMBO …, 2013 - embopress.org
The Polycomb‐repressive complex 2 (PRC2) is important for maintenance of stem cell
pluripotency and suppression of cell differentiation by promoting histone H3 lysine 27 …
pluripotency and suppression of cell differentiation by promoting histone H3 lysine 27 …
[HTML][HTML] Morphological diversity of single neurons in molecularly defined cell types
Dendritic and axonal morphology reflects the input and output of neurons and is a defining
feature of neuronal types 1 , 2 , yet our knowledge of its diversity remains limited. Here, to …
feature of neuronal types 1 , 2 , yet our knowledge of its diversity remains limited. Here, to …
[HTML][HTML] STING agonism reprograms tumor-associated macrophages and overcomes resistance to PARP inhibition in BRCA1-deficient models of breast cancer
PARP inhibitors (PARPi) have drastically changed the treatment landscape of advanced
ovarian tumors with BRCA mutations. However, the impact of this class of inhibitors in patients …
ovarian tumors with BRCA mutations. However, the impact of this class of inhibitors in patients …
[HTML][HTML] Cellular anatomy of the mouse primary motor cortex
An essential step toward understanding brain function is to establish a structural framework
with cellular resolution on which multi-scale datasets spanning molecules, cells, circuits and …
with cellular resolution on which multi-scale datasets spanning molecules, cells, circuits and …
Features versus context: An approach for precise and detailed detection and delineation of faces and facial features
L Ding, AM Martinez - IEEE Transactions on Pattern Analysis …, 2010 - ieeexplore.ieee.org
The appearance-based approach to face detection has seen great advances in the last
several years. In this approach, we learn the image statistics describing the texture pattern (…
several years. In this approach, we learn the image statistics describing the texture pattern (…