Background Current therapies for recurrent Clostridioides difficile infection do not address
the disrupted microbiome, which supports C. difficile spore germination into toxin-producing …

Background & Aims Firmicutes bacteria produce metabolites that maintain the intestinal barrier
and mucosal immunity. Firmicutes are reduced in the intestinal microbiota of patients with …

Background: Recent studies of various human microbiome habitats have revealed thousands
of bacterial species and the existence of large variation in communities of microorganisms …

Yeast sporulation efficiency is a quantitative trait and is known to vary among experimental
populations and natural isolates. Some studies have uncovered the genetic basis of this …

Genome-wide association studies (GWAS) have become an important method for mapping
the genetic loci underlying complex phenotypic traits in many species. A crucial issue when …

Background The gastrointestinal microbiota is an important line of defense against
colonization with antimicrobial resistant (AR) bacteria. In this post hoc analysis of the phase 3 …

microRNAs (miRNAs) are a class of ∼22nt non-coding RNAs that potentially regulate over
60% of human protein-coding genes. miRNA activity is highly specific, differing between cell …

… Nicolas Severe1, Amanda Facklam1, Liz McMichael1, Biplab Das1, Sara Lewandowski1,
Justin Trickett1, Liyang Diao1, Chengfeng Merriman1, Chuan Chen1, Jianwen Feng1 …

PIWI-interacting RNAs (piRNAs) and their associated PIWI proteins play an important role in
repressing transposable elements in animal germlines. However, little is known about the …

Background A healthy gut microbiome is associated with colonization resistance against C.
difficile and other pathogens, including bacteria carrying antibiotic resistance genes (Ab RG )…