User profiles for Liza Darrous
 | Liza DarrousUniversity of Lausanne Verified email at unil.ch Cited by 121 |
[HTML][HTML] Simultaneous estimation of bi-directional causal effects and heritable confounding from GWAS summary statistics
Mendelian Randomisation (MR) is an increasingly popular approach that estimates the
causal effect of risk factors on complex human traits. While it has seen several extensions that …
causal effect of risk factors on complex human traits. While it has seen several extensions that …
[HTML][HTML] Triangulating evidence from longitudinal and Mendelian randomization studies of metabolomic biomarkers for type 2 diabetes
The number of people affected by Type 2 diabetes mellitus (T2DM) is close to half a billion
and is on a sharp rise, representing a major and growing public health burden. Given its mild …
and is on a sharp rise, representing a major and growing public health burden. Given its mild …
Causal inference methods to integrate omics and complex traits
Major biotechnological advances have facilitated a tremendous boost to the collection of (gen-/transcript-/prote-/methyl-/metabol-)omics
data in very large sample sizes worldwide. …
data in very large sample sizes worldwide. …
[HTML][HTML] PheWAS-based clustering of Mendelian Randomisation instruments reveals distinct mechanism-specific causal effects between obesity and educational …
Mendelian Randomisation (MR) estimates causal effects between risk factors and complex
outcomes using genetic instruments. Pleiotropy, heritable confounders, and heterogeneous …
outcomes using genetic instruments. Pleiotropy, heritable confounders, and heterogeneous …
[HTML][HTML] Genetic insights into the causal relationship between physical activity and cognitive functioning
Physical activity and cognitive functioning are strongly intertwined. However, the causal
relationships underlying this association are still unclear. Physical activity can enhance brain …
relationships underlying this association are still unclear. Physical activity can enhance brain …
[HTML][HTML] Composite trait Mendelian randomization reveals distinct metabolic and lifestyle consequences of differences in body shape
Obesity is a major risk factor for a wide range of cardiometabolic diseases, however the
impact of specific aspects of body morphology remains poorly understood. We combined the …
impact of specific aspects of body morphology remains poorly understood. We combined the …
PheWAS-based clustering of Mendelian Randomisation instruments reveals distinct mechanism-specific causal effects between obesity and educational attainment
Mendelian Randomisation (MR) is a statistical method that estimates causal effects
between risk factors and common complex diseases using genetic instruments. Heritable …
between risk factors and common complex diseases using genetic instruments. Heritable …
[PDF][PDF] Genetic insights into the age-specific biological mechanisms governing human ovarian aging
There is currently little evidence that the genetic basis of human phenotype varies significantly
across the lifespan. However, time-to-event phenotypes are understudied and can be …
across the lifespan. However, time-to-event phenotypes are understudied and can be …
Accelerometer-measured physical activity and cognitive functioning: A Mendelian Randomization study
Physical activity and cognitive functioning are strongly intertwined. However, the causal
relationships underlying this association are still unclear. Physical activity can enhance brain …
relationships underlying this association are still unclear. Physical activity can enhance brain …
Identification of metabolomics biomarkers for type 2 diabetes: triangulating evidence from longitudinal and Mendelian randomization analyses
The number of people affected by Type 2 Diabetes Mellitus (T2DM) is close to half a billion
and is on a sharp rise, representing a major and growing public health burden. As the case …
and is on a sharp rise, representing a major and growing public health burden. As the case …