Protein-coding genetic variants that strongly affect disease risk can yield relevant clues to
disease pathogenesis. Here we report exome-sequencing analyses of 20,791 individuals with …

Type 2 diabetes (T2D) affects Latinos at twice the rate seen in populations of European
descent. We recently identified a risk haplotype spanning SLC16A11 that explains ∼20% of the …

Hundreds of thousands of genetic variants have been reported to cause severe monogenic
diseases, but the probability that a variant carrier develops the disease (termed penetrance) …

Associations between human genetic variation and clinical phenotypes have become a
foundation of biomedical research. Most repositories of these data seek to be disease-agnostic …

Type 2 diabetes (T2D) affects more than 415 million people worldwide, and its costs to the
health care system continue to rise. To identify common or rare genetic variation with potential …

To investigate the genetic basis of type 2 diabetes (T2D) to high resolution, the GoT2D and
T2D-GENES consortia catalogued variation from whole-genome sequencing of 2,657 …

Protein-coding genetic variants that strongly affect disease risk can provide important clues
into disease pathogenesis. Here we report an exome sequence analysis of 20,791 type 2 …

… Lizz Caulkins , … Lizz Caulkins …

Introduction: In 2020 the World Health Organization estimated that the number of people
with dementia was 50 million in the world. Furthermore, it is expected about 10 million new …

… Caulkins, et al. 2017. “Sequence data and association statistics from 12,940 type 2
diabetes cases and controls.” Scientific Data 4 (1): 170179. … Gaulton 4 , Lizz Caulkins 2 …