Fibroblasts are an essential cell population for human skin architecture and function. While
fibroblast heterogeneity is well established, this phenomenon has not been analyzed …

TET2/3 play a well-known role in epigenetic regulation and mouse development. However,
their function in cellular differentiation and tissue homeostasis remains poorly understood. …

In multiple myeloma spatial differences in the subclonal architecture, molecular signatures
and composition of the microenvironment remain poorly characterized. To address this …

Cutaneous squamous cell carcinoma (cSCC) is a serious public health problem due to its
high incidence and metastatic potential. It may progress from actinic keratosis (AK), a …

The dermal sheath (DS) is a population of mesenchyme-derived skin cells with emerging
importance for skin homeostasis. The DS includes hair follicle dermal stem cells, which exhibit …

Keratinocyte cancers (KC) are the most prevalent malignancies in fair‐skinned populations,
posing a significant medical and economic burden to health systems. KC originate in the …

Endothelial dysfunction is characterised by aberrant redox signalling and an inflammatory
phenotype. Shear stress antagonises endothelial dysfunction by increasing nitric oxide …

In this issue of Nature Genetics, Lara-Astiaso et al. systematically characterized the functional
roles of several chromatin factors in hematopoiesis by combining functional CRISPR …

Mutations in, and the altered expression of, epigenetic modifiers are pervasive in human
tumours, making epigenetic factors attractive antitumour targets. The open-versus-closed …

The IL-6–gp130–STAT3 signaling axis is a major regulator of inflammation. Activating
mutations in the gene encoding gp130 and germline gain-of-function mutations in STAT3 (STAT3 …