Cancer susceptibility has been attributed to at least one heterozygous genetic alteration in a
tumor suppressor gene (TSG) 1 . It has been hypothesized that subtle variations in TSG …

The proto-oncogene AKT (also known as PKB) is activated in many human cancers, mostly
owing to loss of the PTEN tumour suppressor 1 . In such tumours, AKT becomes enriched at …

Adenovirus type 2 (Ad2) imports its DNA genome through the nuclear pore complex (NPC)
of cells in interphase for viral production. Here we identify the NPC-filament protein CAN/…

Cellular senescence has been theorized to oppose neoplastic transformation triggered by
activation of oncogenic pathways in vitro 1 , 2 , 3 , but the relevance of senescence in vivo has …

INTRODUCTION Most cancer patients die from cancer that recurs after spreading to a different
tissue, rather than from their original tumor. After successful treatment of the original tumor…

Complete inactivation of the PTEN tumor suppressor gene is extremely common in advanced
cancer, including prostate cancer (CaP). However, one PTEN allele is already lost in the …

The PTEN tumor suppressor is frequently affected in cancer cells, and inherited PTEN
mutation causes cancer-susceptibility conditions such as Cowden syndrome. PTEN acts as a …

Huntington's disease (HD) is characterized by the accumulation of a pathogenic protein,
Huntingtin (Htt), that contains an abnormal polyglutamine expansion. Here, we report that a …

The tumor suppressor PTEN, a critical regulator for multiple cellular processes, is mutated or
deleted frequently in various human cancers. Subtle reductions in PTEN expression levels …

Irreversible cell growth arrest, a process termed cellular senescence, is emerging as an
intrinsic tumor suppressive mechanism. Oncogene-induced senescence is thought to be …