User profiles for Lluis Espinosa

lluis espinosa blay

Institut Mar d'Investigacions Mediques
Verified email at imim.es
Cited by 6256

Hematopoietic stem cells: to be or Notch to be

A Bigas, L Espinosa - Blood, The Journal of the American …, 2012 - ashpublications.org
Notch is a well-conserved signaling pathway and its function in cell fate determination is crucial
in embryonic development and in the maintenance of tissue homeostasis during adult life…

[PDF][PDF] The Notch pathway in the developing hematopoietic system

A Bigas, À Robert-Moreno, L Espinosa - International Journal of …, 2010 - ijdb.ehu.es
The main function of the Notch signaling pathway is to generate cell diversity during both
embryonic development and adult tissue homeostasis. The extended use of this pathway, …

The multiple usages of Notch signaling in development, cell differentiation and cancer

A Bigas, L Espinosa - Current opinion in cell biology, 2018 - Elsevier
Notch is a well-conserved signaling pathway all through evolution that is crucial to specify
different cell fates. Although there is a strong context dependent component in each decision, …

Dll1-and dll4-mediated notch signaling are required for homeostasis of intestinal stem cells

…, V Rodilla, Z Liu, S Chen, U Koch, L Espinosa… - Gastroenterology, 2011 - Elsevier
Background & Aims Ablation of Notch signaling within the intestinal epithelium results in loss
of proliferating crypt progenitors due to their conversion into postmitotic secretory cells. We …

RBPJκ-dependent signaling is essential for long-term maintenance of neural stem cells in the adult hippocampus

…, E Kremmer, FW Pfrieger, L Espinosa… - Journal of …, 2010 - Soc Neuroscience
The generation of new neurons from neural stem cells in the adult hippocampal dentate
gyrus contributes to learning and mood regulation. To sustain hippocampal neurogenesis …

[PDF][PDF] The Notch/Hes1 pathway sustains NF-κB activation through CYLD repression in T cell leukemia

L Espinosa, S Cathelin, T D'Altri, T Trimarchi… - Cancer cell, 2010 - cell.com
It was previously shown that the NF-κB pathway is downstream of oncogenic Notch1 in T cell
acute lymphoblastic leukemia (T-ALL). Here, we visualize Notch-induced NF-κB activation …

Impaired embryonic haematopoiesis yet normal arterial development in the absence of the Notch ligand Jagged1

…, T Enver, E Dzierzak, T Gridley, L Espinosa… - The EMBO …, 2008 - embopress.org
Specific deletion of Notch1 and RBPjκ in the mouse results in abrogation of definitive
haematopoiesis concomitant with the loss of arterial identity at embryonic stage. As prior arterial …

Jagged1 is the pathological link between Wnt and Notch pathways in colorectal cancer

…, G Capella, A Bigas, L Espinosa - Proceedings of the …, 2009 - National Acad Sciences
Notch has been linked to β-catenin-dependent tumorigenesis; however, the mechanisms
leading to Notch activation and the contribution of the Notch pathway to colorectal cancer is not …

[HTML][HTML] Phosphorylation by glycogen synthase kinase-3β down-regulates Notch activity, a link for Notch and Wnt pathways

L Espinosa, J Inglés-Esteve, C Aguilera… - Journal of Biological …, 2003 - ASBMB
Phosphorylation of Notch proteins has been indirectly correlated with Notch activation and
nuclear translocation as well as cellular transformation. There is evidence that the Wnt …

RBPjκ-dependent Notch function regulates Gata2 and is essential for the formation of intra-embryonic hematopoietic cells

À Robert-Moreno, L Espinosa, JL de la Pompa, A Bigas - 2005 - journals.biologists.com
Definitive hematopoiesis in the mouse embryo originates from the aortic floor in the P-Sp/AGM
region in close association with endothelial cells. An important role for Notch1 in the …