User profiles for Lluis Espinosa
lluis espinosa blayInstitut Mar d'Investigacions Mediques Verified email at imim.es Cited by 6256 |
Hematopoietic stem cells: to be or Notch to be
A Bigas, L Espinosa - Blood, The Journal of the American …, 2012 - ashpublications.org
Notch is a well-conserved signaling pathway and its function in cell fate determination is crucial
in embryonic development and in the maintenance of tissue homeostasis during adult life…
in embryonic development and in the maintenance of tissue homeostasis during adult life…
[PDF][PDF] The Notch pathway in the developing hematopoietic system
A Bigas, À Robert-Moreno, L Espinosa - International Journal of …, 2010 - ijdb.ehu.es
The main function of the Notch signaling pathway is to generate cell diversity during both
embryonic development and adult tissue homeostasis. The extended use of this pathway, …
embryonic development and adult tissue homeostasis. The extended use of this pathway, …
The multiple usages of Notch signaling in development, cell differentiation and cancer
A Bigas, L Espinosa - Current opinion in cell biology, 2018 - Elsevier
Notch is a well-conserved signaling pathway all through evolution that is crucial to specify
different cell fates. Although there is a strong context dependent component in each decision, …
different cell fates. Although there is a strong context dependent component in each decision, …
Dll1-and dll4-mediated notch signaling are required for homeostasis of intestinal stem cells
Background & Aims Ablation of Notch signaling within the intestinal epithelium results in loss
of proliferating crypt progenitors due to their conversion into postmitotic secretory cells. We …
of proliferating crypt progenitors due to their conversion into postmitotic secretory cells. We …
RBPJκ-dependent signaling is essential for long-term maintenance of neural stem cells in the adult hippocampus
…, E Kremmer, FW Pfrieger, L Espinosa… - Journal of …, 2010 - Soc Neuroscience
The generation of new neurons from neural stem cells in the adult hippocampal dentate
gyrus contributes to learning and mood regulation. To sustain hippocampal neurogenesis …
gyrus contributes to learning and mood regulation. To sustain hippocampal neurogenesis …
[PDF][PDF] The Notch/Hes1 pathway sustains NF-κB activation through CYLD repression in T cell leukemia
L Espinosa, S Cathelin, T D'Altri, T Trimarchi… - Cancer cell, 2010 - cell.com
It was previously shown that the NF-κB pathway is downstream of oncogenic Notch1 in T cell
acute lymphoblastic leukemia (T-ALL). Here, we visualize Notch-induced NF-κB activation …
acute lymphoblastic leukemia (T-ALL). Here, we visualize Notch-induced NF-κB activation …
Impaired embryonic haematopoiesis yet normal arterial development in the absence of the Notch ligand Jagged1
…, T Enver, E Dzierzak, T Gridley, L Espinosa… - The EMBO …, 2008 - embopress.org
Specific deletion of Notch1 and RBPjκ in the mouse results in abrogation of definitive
haematopoiesis concomitant with the loss of arterial identity at embryonic stage. As prior arterial …
haematopoiesis concomitant with the loss of arterial identity at embryonic stage. As prior arterial …
Jagged1 is the pathological link between Wnt and Notch pathways in colorectal cancer
Notch has been linked to β-catenin-dependent tumorigenesis; however, the mechanisms
leading to Notch activation and the contribution of the Notch pathway to colorectal cancer is not …
leading to Notch activation and the contribution of the Notch pathway to colorectal cancer is not …
[HTML][HTML] Phosphorylation by glycogen synthase kinase-3β down-regulates Notch activity, a link for Notch and Wnt pathways
L Espinosa, J Inglés-Esteve, C Aguilera… - Journal of Biological …, 2003 - ASBMB
Phosphorylation of Notch proteins has been indirectly correlated with Notch activation and
nuclear translocation as well as cellular transformation. There is evidence that the Wnt …
nuclear translocation as well as cellular transformation. There is evidence that the Wnt …
RBPjκ-dependent Notch function regulates Gata2 and is essential for the formation of intra-embryonic hematopoietic cells
Definitive hematopoiesis in the mouse embryo originates from the aortic floor in the P-Sp/AGM
region in close association with endothelial cells. An important role for Notch1 in the …
region in close association with endothelial cells. An important role for Notch1 in the …