User profiles for Lluis Quintana-Murci

Lluis Quintana-Murci

Collège de France and Institut Pasteur (CNRS UMR2000)
Verified email at pasteur.fr
Cited by 28786

Natural selection has driven population differentiation in modern humans

…, G Laval, H Quach, E Patin, L Quintana-Murci - Nature …, 2008 - nature.com
The considerable range of observed phenotypic variation in human populations may reflect,
in part, distinctive processes of natural selection and adaptation to variable environmental …

From evolutionary genetics to human immunology: how selection shapes host defence genes

LB Barreiro, L Quintana-Murci - Nature Reviews Genetics, 2010 - nature.com
Pathogens have always been a major cause of human mortality, so they impose strong
selective pressure on the human genome. Data from population genetic studies, including …

[HTML][HTML] Evolutionary dynamics of human Toll-like receptors and their different contributions to host defense

…, L Abel, JL Casanova, L Quintana-Murci - PLoS …, 2009 - journals.plos.org
Infectious diseases have been paramount among the threats to health and survival throughout
human evolutionary history. Natural selection is therefore expected to act strongly on host …

Natural variation in the parameters of innate immune cells is preferentially driven by genetic factors

…, S Thomas, J Fellay, D Duffy, L Quintana-Murci… - Nature …, 2018 - nature.com
The quantification and characterization of circulating immune cells provide key indicators of
human health and disease. To identify the relative effects of environmental and genetic …

Genetic evidence of an early exit of Homo sapiens sapiens from Africa through eastern Africa

L Quintana-Murci, O Semino, HJ Bandelt, G Passarino… - Nature …, 1999 - nature.com
The out-of-Africa scenario 1 has hitherto provided little evidence for the precise route by
which modern humans left Africa. Two major routes of dispersal have been hypothesized: one …

Autoantibodies against type I IFNs in patients with life-threatening COVID-19

…, J Hadjadj, B Terrier, D Duffy, L Quintana-Murci… - Science, 2020 - science.org
INTRODUCTION Interindividual clinical variability is vast in humans infected with severe
acute respiratory syndrome coronavirus 2 (SARS-CoV-2), ranging from silent infection to rapid …

[HTML][HTML] Sexual inequality in tuberculosis

O Neyrolles, L Quintana-Murci - PLoS medicine, 2009 - journals.plos.org
Lluis Quintana-MurciLluis Quintana-Murci … Copyright: © 2009 Neyrolles, Quintana-Murci.
This is an open-access article distributed under the terms of the Creative Commons …

Dispersals and genetic adaptation of Bantu-speaking populations in Africa and North America

…, CD Bustamante, JM Hombert, L Quintana-Murci - Science, 2017 - science.org
Bantu languages are spoken by about 310 million Africans, yet the genetic history of Bantu-speaking
populations remains largely unexplored. We generated genomic data for 1318 …

[PDF][PDF] The matrilineal ancestry of Ashkenazi Jewry: portrait of a recent founder event

…, S Tzur, L Pereira, A Amorim, L Quintana-Murci… - The American Journal of …, 2006 - cell.com
Both the extent and location of the maternal ancestral deme from which the Ashkenazi
Jewry arose remain obscure. Here, using complete sequences of the maternally inherited …

[HTML][HTML] Genetic adaptation and Neandertal admixture shaped the immune system of human populations

…, JF Deleuze, J Kelso, ML Albert, L Quintana-Murci - Cell, 2016 - cell.com
Humans differ in the outcome that follows exposure to life-threatening pathogens, yet the
extent of population differences in immune responses and their genetic and evolutionary …