Osteoporosis is a common aging-related disease diagnosed primarily using bone mineral
density (BMD). We assessed genetic determinants of BMD as estimated by heel quantitative …

Even if the carboxyl-terminal (C-) fragments/intact (I-) PTH ratio is tightly regulated by the
ionized calcium (Ca 2+ ) concentration in humans and animals, in health and in disease, the …

Vitamin D signaling regulates cell proliferation and differentiation, and epidemiological data
suggest that it functions as a cancer chemopreventive agent, although the underlying …

We examined the role of bone remodeling in the regulation of circulating concentrations of
FGF23 using mouse models manifesting differing degrees of coupled and uncoupled bone …

Circulating levels of fibroblast growth factor 23 (FGF23) increase during the early stages of
kidney disease, but the underlying mechanism remains incompletely characterized. We …

… Author links open overlay panel Pierre D'Amour , Jean-Hugues Brossard , Louise Rousseau
, Loan Nguyen-Yamamoto , Edgard Nassif , Claude Lazure , Dany Gauthier , Jeffrey R. …

We induced chronic kidney disease (CKD) with adenine in WT mice, mice with osteocyte-specific
deletion of Cyp27b1, encoding the 25-hydroxyvitamin D 1 (OH) ase [Oct-1 (OH) ase–/–]…

Osteoporosis and sarcopenia are common comorbid diseases, yet their shared mechanisms
are largely unknown. We found that genetic variation near FAM210A was associated, …

Increased risk of bone fractures is observed in patients with chronic inflammatory conditions,
such as inflammatory bowel disease and rheumatoid arthritis. Members of the Interferon …

The retinoid X receptor α (RXRα) is a member of the nuclear receptor superfamily that regulates
transcription of target genes through heterodimerization with several partners, including …