The inference of genetic interactions from measured expression data is one of the most
challenging tasks of modern functional genomics. When successful, the learned network of …

Mutations of the retinoblastoma tumor-suppressor gene (RB1) or components regulating the
CDK-RB-E2F pathway have been identified in nearly every human malignancy. Re-…

Systematic studies of cancer genomes have provided unprecedented insights into the
molecular nature of cancer. Using this information to guide the development and application of …

Breast cancer is the most common cancer among women. Common variants at 27 loci have
been identified as associated with susceptibility to breast cancer, and these account for ∼9…

Abstract Treatment of BRAF(V600E) mutant melanoma by small molecule drugs that target
the BRAF or MEK kinases can be effective, but resistance develops invariably 1 , 2 . In …

Recent studies of the tumor genome seek to identify cancer pathways as groups of genes in
which mutations are epistatic with one another or, specifically, "mutually exclusive." Here, …

The efficacy of programmed cell death protein 1 (PD-1) blockade in metastatic triple-negative
breast cancer (TNBC) is low 1 , 2 , 3 , 4 – 5 , highlighting a need for strategies that render …

The clinical benefit for patients with diverse types of metastatic cancers that has been
observed upon blockade of the interaction between PD-1 and PD-L1 has highlighted the …

Background A 70-gene tumor expression profile was established as a powerful predictor of
disease outcome in young breast cancer patients. This profile, however, was generated on …

It has been debated for decades how cancer cells acquire metastatic capability. It is unclear
whether metastases are derived from distinct subpopulations of tumor cells within the …