[HTML][HTML] High-throughput screening of the ReFRAME, Pandemic Box, and COVID Box drug repurposing libraries against SARS-CoV-2 nsp15 endoribonuclease to …

R Choi, M Zhou, R Shek, JW Wilson, L Tillery… - PLoS …, 2021 - journals.plos.org
SARS-CoV-2 has caused a global pandemic, and has taken over 1.7 million lives as of mid-December,
2020. Although great progress has been made in the development of effective …

[HTML][HTML] In silico detection of SARS-CoV-2 specific B-cell epitopes and validation in ELISA for serological diagnosis of COVID-19

…, L Carter, I Anishchenko, LK Barrett, J Craig, L Tillery… - Scientific reports, 2021 - nature.com
Rapid generation of diagnostics is paramount to understand epidemiology and to control
the spread of emerging infectious diseases such as COVID-19. Computational methods to …

[HTML][HTML] Naegleria fowleri: Protein structures to facilitate drug discovery for the deadly, pathogenic free-living amoeba

L Tillery, K Barrett, J Goldstein, JW Lassner… - PLoS …, 2021 - journals.plos.org
Naegleria fowleri is a pathogenic, thermophilic, free-living amoeba which causes primary
amebic meningoencephalitis (PAM). Penetrating the olfactory mucosa, the brain-eating …

[HTML][HTML] The transcriptome of Balamuthia mandrillaris trophozoites for structure-guided drug design

…, RE Noorai, JR McDonald, S Subramanian, L Tillery… - Scientific Reports, 2021 - nature.com
Balamuthia mandrillaris, a pathogenic free-living amoeba, causes cutaneous skin lesions
as well as granulomatous amoebic encephalitis, a ‘brain-eating’ disease. As with the other …

Shotgun Kinetic Target-Guided Synthesis Approach Enables the Discovery of Small-Molecule Inhibitors against Pathogenic Free-Living Amoeba Glucokinases

…, B Miller, K Carter, KF Barrett, LM Tillery… - ACS Infectious …, 2023 - ACS Publications
Pathogenic free-living amoebae (pFLA) can cause life-threatening central nervous system (CNS)
infections and warrant the investigation of new chemical agents to combat the rise of …

Structures of glyceraldehyde 3‐phosphate dehydrogenase in Neisseria gonorrhoeae and Chlamydia trachomatis

…, S Shaheen, ED Navaluna, JK Craig, LM Tillery… - Protein …, 2020 - Wiley Online Library
Neisseria gonorrhoeae (Ng) and Chlamydia trachomatis (Ct) are the most commonly reported
sexually transmitted bacteria worldwide and usually present as co‐infections. Increasing …

Toward a structome of Acinetobacter baumannii drug targets

LM Tillery, KF Barrett, DM Dranow, J Craig… - Protein …, 2020 - Wiley Online Library
Acinetobacter baumannii is well known for causing hospital‐associated infections due in
part to its intrinsic antibiotic resistance as well as its ability to remain viable on surfaces and …

Alanine to serine substitutions drive thermal adaptation in a psychrophilic diatom cytochrome c6

M Wilson, L Tillery, E Tabaie, G Beery… - JBIC Journal of …, 2020 - Springer
In this study, we investigate the thermodynamic mechanisms by which electron transfer
proteins adapt to environmental temperature by directly comparing the redox properties and …

The transcriptome of Balamuthia mandrillaris trophozoites for structure-based drug design

…, RE Noorai, J McDonald, S Subramanian, L Tillery… - bioRxiv, 2020 - biorxiv.org
Balamuthia mandrillaris, a pathogenic free-living amoeba (FLA), causes cutaneous skin
lesions as well as the brain-eating disease: Balamuthia granulomatous amoebic encephalitis (…

Naegleria fowleri: protein structures to facilitate drug discovery for the deadly, pathogenic free-living amoeba

K Barrett, L Tillery, J Goldstein, JW Lassner… - bioRxiv, 2020 - biorxiv.org
Naegleria fowleri is a pathogenic, thermophilic, free-living amoeba which causes primary
amebic meningoencephalitis (PAM). Penetrating the olfactory mucosa, the brain-eating …