User profiles for Lohitash Karumbaiah

Lohitash Karumbaiah

Associate Professor, University of Georgia, Regenerative Bioscience Center
Verified email at uga.edu
Cited by 2445

The impact of chronic blood–brain barrier breach on intracortical electrode function

T Saxena, L Karumbaiah, EA Gaupp, R Patkar, K Patil… - Biomaterials, 2013 - Elsevier
Brain-computer interfaces (BCIs) have allowed control of prosthetic limbs in paralyzed
patients. Unfortunately, the electrodes of the BCI that interface with the brain only function for a …

Relationship between intracortical electrode design and chronic recording function

L Karumbaiah, T Saxena, D Carlson, K Patil, R Patkar… - Biomaterials, 2013 - Elsevier
Intracortical electrodes record neural signals directly from local populations of neurons in
the brain, and conduct them to external electronics that control prosthetics. However, the …

[HTML][HTML] Reduced Levels of Membrane-Bound Alkaline Phosphatase Are Common to Lepidopteran Strains Resistant to Cry Toxins from Bacillus thuringiensis

JL Jurat-Fuentes, L Karumbaiah, SRK Jakka, C Ning… - PLoS …, 2011 - journals.plos.org
Development of insect resistance is one of the main concerns with the use of transgenic
crops expressing Cry toxins from the bacterium Bacillus thuringiensis. Identification of …

Photocrosslinkable chitosan based hydrogels for neural tissue engineering

…, VJ Mukhatyar, A Jain, L Karumbaiah… - Soft Matter, 2012 - pubs.rsc.org
Hydrogel based scaffolds for neural tissue engineering can provide appropriate physico-chemical
and mechanical properties to support neurite extension and facilitate transplantation …

The upregulation of specific interleukin (IL) receptor antagonists and paradoxical enhancement of neuronal apoptosis due to electrode induced strain and brain …

L Karumbaiah, SE Norman, NB Rajan, S Anand… - Biomaterials, 2012 - Elsevier
The high mechanical mismatch between stiffness of silicon and metal microelectrodes and
soft cortical tissue, induces strain at the neural interface which likely contributes to failure of …

Anti-invasive adjuvant therapy with imipramine blue enhances chemotherapeutic efficacy against glioma

…, SA Rowson, MY Bonner, L Karumbaiah… - Science translational …, 2012 - science.org
The invasive nature of glioblastoma (GBM) represents a major clinical challenge contributing
to poor outcomes. Invasion of GBM into healthy tissue restricts chemotherapeutic access …

Evaluation of tumor microenvironment in an animal model using a nanoparticle contrast agent in computed tomography imaging

KB Ghaghada, CT Badea, L Karumbaiah, N Fettig… - Academic radiology, 2011 - Elsevier
RATIONALE AND OBJECTIVES: Non-invasive longitudinal imaging of tumor vasculature
could provide new insights into the development of solid tumors, facilitating efficient delivery of …

Intracortical recording interfaces: current challenges to chronic recording function

…, T Saxena, R Bellamkonda, L Karumbaiah - ACS chemical …, 2015 - ACS Publications
Brain Computer Interfaces (BCIs) offer significant hope to tetraplegic and paraplegic individuals.
This technology relies on extracting and translating motor intent to facilitate control of a …

Nanocarrier-mediated inhibition of macrophage migration inhibitory factor attenuates secondary injury after spinal cord injury

T Saxena, KH Loomis, SB Pai, L Karumbaiah… - ACS …, 2015 - ACS Publications
Spinal cord injury (SCI) can lead to permanent motor and sensory deficits. Following the
initial traumatic insult, secondary injury mechanisms characterized by persistent heightened …

[HTML][HTML] Tumor vascular permeability to a nanoprobe correlates to tumor-specific expression levels of angiogenic markers

E Karathanasis, L Chan, L Karumbaiah, K McNeeley… - PLoS …, 2009 - journals.plos.org
Background Vascular endothelial growth factor (VEGF) receptor-2 is the major mediator of
the mitogenic, angiogenic, and vascular hyperpermeability effects of VEGF on breast tumors. …