We have proposed engineering tissues by the incorporation and sustained release of
plasmids encoding tissue-inductive proteins from polymer matrices. Matrices of poly (lactide-co-…

The ultimate goal of this study is to regenerate lost dental pulp and dentin via stem/progenitor
cell–based approaches and tissue engineering technologies. In this study, we tested the …

Cancer immunotherapy is revolutionizing oncology. However, dose-limiting toxicities and
low patient response rates remain major challenges in the clinic. Cancer nanomedicine in …

The physiological activity of hyaluronic acid (HA) polymers and oligomers makes it a promising
material for a variety of applications. The development of HA–hydrogel scaffolds with …

Aberrant T-cell activation underlies many autoimmune disorders, yet most attempts to induce
T-cell tolerance have failed. Building on previous strategies for tolerance induction that …

Macroporous scaffolds are typically utilized in tissue engineering applications to allow for the
migration of cells throughout the scaffold and integration of the engineered tissue with the …

Type 1 diabetes is an autoimmune disorder in which the immune system attacks and destroys
insulin-producing islet cells of the pancreas. Although islet transplantation has proved to …

Oocytes grown in vitro are of low quality and yield few live births, thus limiting the ability to
store or bank the ova of women wishing to preserve their fertility. We applied tissue …

The mechanical properties and density of natural and synthetic extracellular matrices are
known to affect cellular processes and regulate tissue formation. In this report, these factors …

The lung epithelium is derived from the endodermal germ layer, which undergoes a complex
series of endoderm–mesoderm-mediated signaling events to generate the final arborized …