[HTML][HTML] Reproducibility of CRISPR-Cas9 methods for generation of conditional mouse alleles: a multi-center evaluation

…, R Sedlacek, K Sharma, C Smith, K Staes, L Starrs… - Genome biology, 2019 - Springer
Background CRISPR-Cas9 gene-editing technology has facilitated the generation of knockout
mice, providing an alternative to cumbersome and time-consuming traditional embryonic …

Unstable chromosome rearrangements in Staphylococcus aureus cause phenotype switching associated with persistent infections

…, IR Monk, M Kunimoto, L Starrs… - Proceedings of the …, 2019 - National Acad Sciences
Staphylococcus aureus small-colony variants (SCVs) are associated with unusually chronic
and persistent infections despite active antibiotic treatment. The molecular basis for this …

Molecular changes during TGFβ‐mediated lung fibroblast‐myofibroblast differentiation: implication for glucocorticoid resistance

JD Breton, D Heydet, LM Starrs, T Veldre… - Physiological …, 2018 - Wiley Online Library
Airway remodeling is an important process in response to repetitive inflammatory‐mediated
airway wall injuries. This is characterized by profound changes and reorganizations at the …

[HTML][HTML] Respiratory syncytial virus matrix protein-chromatin association is key to transcriptional inhibition in infected cells

HM Li, R Ghildyal, M Hu, KC Tran, LM Starrs, J Mills… - Cells, 2021 - mdpi.com
The morbidity and mortality caused by the globally prevalent human respiratory pathogen
respiratory syncytial virus (RSV) approaches that world-wide of influenza. We previously …

[HTML][HTML] Loss of intra-islet heparan sulfate is a highly sensitive marker of type 1 diabetes progression in humans

CJ Simeonovic, SK Popp, LM Starrs, DJ Brown… - PloS one, 2018 - journals.plos.org
Type 1 diabetes (T1D) is an autoimmune disease in which insulin-producing beta cells in
pancreatic islets are progressively destroyed. Clinical trials of immunotherapies in recently …

Tug of war between Acinetobacter baumannii and host immune responses

FJ Li, L Starrs, G Burgio - Pathogens and disease, 2018 - academic.oup.com
Acinetobacter baumannii is an emerging nosocomial, opportunistic pathogen with growing
clinical significance. Acinetobacter baumannii has an exceptional ability to rapidly develop …

Cas9 Cuts and Consequences; Detecting, Predicting, and Mitigating CRISPR/Cas9 On‐and Off‐Target Damage: Techniques for Detecting, Predicting, and Mitigating …

A Newman, L Starrs, G Burgio - Bioessays, 2020 - Wiley Online Library
Large deletions and genomic re‐arrangements are increasingly recognized as common
products of double‐strand break repair at Clustered Regularly Interspaced, Short Palindromic …

Exploring heteroaromatic rings as a replacement for the labile amide of antiplasmodial pantothenamides

…, T Kittikool, VM Howieson, H Ling, L Starrs… - Journal of Medicinal …, 2021 - ACS Publications
Malaria-causing Plasmodium parasites are developing resistance to antimalarial drugs,
providing the impetus for new antiplasmodials. Although pantothenamides show potent …

[HTML][HTML] Differential activation of NLRP3 inflammasome by Acinetobacter baumannii strains

FJ Li, L Starrs, A Mathur, H Ishii, SM Man, G Burgio - Plos one, 2022 - journals.plos.org
Acinetobacter baumannii is an emerging nosocomial, opportunistic pathogen with growing
clinical significance globally. A. baumannii has an exceptional ability to rapidly develop drug …

[HTML][HTML] KCC1 activation protects mice from the development of experimental cerebral malaria

E Hortle, L Starrs, FC Brown, SM Jane, DJ Curtis… - Scientific reports, 2019 - nature.com
Plasmodium falciparum malaria causes half a million deaths per year, with up to 9% of this
mortality caused by cerebral malaria (CM). One of the major processes contributing to the …