[HTML][HTML] Reproducibility of CRISPR-Cas9 methods for generation of conditional mouse alleles: a multi-center evaluation
…, R Sedlacek, K Sharma, C Smith, K Staes, L Starrs… - Genome biology, 2019 - Springer
Background CRISPR-Cas9 gene-editing technology has facilitated the generation of knockout
mice, providing an alternative to cumbersome and time-consuming traditional embryonic …
mice, providing an alternative to cumbersome and time-consuming traditional embryonic …
Unstable chromosome rearrangements in Staphylococcus aureus cause phenotype switching associated with persistent infections
…, IR Monk, M Kunimoto, L Starrs… - Proceedings of the …, 2019 - National Acad Sciences
Staphylococcus aureus small-colony variants (SCVs) are associated with unusually chronic
and persistent infections despite active antibiotic treatment. The molecular basis for this …
and persistent infections despite active antibiotic treatment. The molecular basis for this …
Molecular changes during TGFβ‐mediated lung fibroblast‐myofibroblast differentiation: implication for glucocorticoid resistance
JD Breton, D Heydet, LM Starrs, T Veldre… - Physiological …, 2018 - Wiley Online Library
Airway remodeling is an important process in response to repetitive inflammatory‐mediated
airway wall injuries. This is characterized by profound changes and reorganizations at the …
airway wall injuries. This is characterized by profound changes and reorganizations at the …
[HTML][HTML] Respiratory syncytial virus matrix protein-chromatin association is key to transcriptional inhibition in infected cells
HM Li, R Ghildyal, M Hu, KC Tran, LM Starrs, J Mills… - Cells, 2021 - mdpi.com
The morbidity and mortality caused by the globally prevalent human respiratory pathogen
respiratory syncytial virus (RSV) approaches that world-wide of influenza. We previously …
respiratory syncytial virus (RSV) approaches that world-wide of influenza. We previously …
[HTML][HTML] Loss of intra-islet heparan sulfate is a highly sensitive marker of type 1 diabetes progression in humans
CJ Simeonovic, SK Popp, LM Starrs, DJ Brown… - PloS one, 2018 - journals.plos.org
Type 1 diabetes (T1D) is an autoimmune disease in which insulin-producing beta cells in
pancreatic islets are progressively destroyed. Clinical trials of immunotherapies in recently …
pancreatic islets are progressively destroyed. Clinical trials of immunotherapies in recently …
Tug of war between Acinetobacter baumannii and host immune responses
FJ Li, L Starrs, G Burgio - Pathogens and disease, 2018 - academic.oup.com
Acinetobacter baumannii is an emerging nosocomial, opportunistic pathogen with growing
clinical significance. Acinetobacter baumannii has an exceptional ability to rapidly develop …
clinical significance. Acinetobacter baumannii has an exceptional ability to rapidly develop …
Cas9 Cuts and Consequences; Detecting, Predicting, and Mitigating CRISPR/Cas9 On‐and Off‐Target Damage: Techniques for Detecting, Predicting, and Mitigating …
Large deletions and genomic re‐arrangements are increasingly recognized as common
products of double‐strand break repair at Clustered Regularly Interspaced, Short Palindromic …
products of double‐strand break repair at Clustered Regularly Interspaced, Short Palindromic …
Exploring heteroaromatic rings as a replacement for the labile amide of antiplasmodial pantothenamides
…, T Kittikool, VM Howieson, H Ling, L Starrs… - Journal of Medicinal …, 2021 - ACS Publications
Malaria-causing Plasmodium parasites are developing resistance to antimalarial drugs,
providing the impetus for new antiplasmodials. Although pantothenamides show potent …
providing the impetus for new antiplasmodials. Although pantothenamides show potent …
[HTML][HTML] Differential activation of NLRP3 inflammasome by Acinetobacter baumannii strains
Acinetobacter baumannii is an emerging nosocomial, opportunistic pathogen with growing
clinical significance globally. A. baumannii has an exceptional ability to rapidly develop drug …
clinical significance globally. A. baumannii has an exceptional ability to rapidly develop drug …
[HTML][HTML] KCC1 activation protects mice from the development of experimental cerebral malaria
Plasmodium falciparum malaria causes half a million deaths per year, with up to 9% of this
mortality caused by cerebral malaria (CM). One of the major processes contributing to the …
mortality caused by cerebral malaria (CM). One of the major processes contributing to the …