Single-cell profiling identifies a novel human polyclonal unconventional T cell lineage
L Billiet, L De Cock, G Sanchez Sanchez… - Journal of Experimental …, 2023 - rupress.org
In the human thymus, a CD10 + PD-1 + TCRαβ + differentiation pathway diverges from the
conventional single positive T cell lineages at the early double-positive stage. Here, we …
conventional single positive T cell lineages at the early double-positive stage. Here, we …
[HTML][HTML] Rapid and effective generation of nanobody based CARs using PCR and Gibson assembly
…, G Goetgeluk, S Bonte, M Pille, L Billiet… - International journal of …, 2020 - mdpi.com
Recent approval of chimeric antigen receptor (CAR) T cell therapy by the European Medicines
Agency (EMA)/Federal and Drug Administration (FDA) and the remarkable results of CAR …
Agency (EMA)/Federal and Drug Administration (FDA) and the remarkable results of CAR …
[HTML][HTML] Small-scale manufacturing of neoantigen-encoding messenger RNA for early-phase clinical trials
…, S De Smet, M Brusseel, S De Munter, M Pille, L Billiet… - Cytotherapy, 2022 - Elsevier
Messenger RNA (mRNA) has become a promising tool in therapeutic cancer vaccine strategies.
Owing to its flexible design and rapid production, mRNA is an attractive antigen delivery …
Owing to its flexible design and rapid production, mRNA is an attractive antigen delivery …
[HTML][HTML] Neoantigen-targeted dendritic cell vaccination in lung cancer patients induces long-lived T cells exhibiting the full differentiation spectrum
…, S Van Lint, G Goetgeluk, S Bonte, L Billiet… - Cell Reports …, 2024 - cell.com
Non-small cell lung cancer (NSCLC) is known for high relapse rates despite resection in
early stages. Here, we present the results of a phase I clinical trial in which a dendritic cell (DC) …
early stages. Here, we present the results of a phase I clinical trial in which a dendritic cell (DC) …
[HTML][HTML] The Wiskott–Aldrich syndrome protein is required for positive selection during T-cell lineage differentiation
…, G Goetgeluk, S De Munter, H Jansen, L Billiet… - Frontiers in …, 2023 - frontiersin.org
The Wiskott–Aldrich syndrome (WAS) is an X-linked primary immune deficiency caused by a
mutation in the WAS gene. This leads to altered or absent WAS protein (WASp) expression …
mutation in the WAS gene. This leads to altered or absent WAS protein (WASp) expression …
Knocking out CD70 rescues CD70-specific nanoCAR T cells from antigen induced exhaustion
…, E Pascal, L Deseins, J Ingels, G Goetgeluk, L Billiet… - bioRxiv, 2023 - biorxiv.org
CD70 is an attractive target for chimeric antigen receptor (CAR) T cell therapy as treatment
for both solid and liquid malignancies. However, functionality of CD70-specific CARs is only …
for both solid and liquid malignancies. However, functionality of CD70-specific CARs is only …
[HTML][HTML] Human Thymic CD10+ PD-1+ Intraepithelial Lymphocyte Precursors Acquire Interleukin-15 Responsiveness at the CD1a– CD95+ CD28– CCR7– …
L Billiet, G Goetgeluk, S Bonte, S De Munter… - International Journal of …, 2020 - mdpi.com
Human thymic CD8αα + CD10 + PD-1 + αβ T cells selected through early agonist selection
have been proposed as the putative thymic precursors of the human CD8αα + intestinal …
have been proposed as the putative thymic precursors of the human CD8αα + intestinal …
In vitro OP9-DL1 co-culture and subsequent maturation in the presence of IL-21 generates tumor antigen-specific T cells with a favorable less-differentiated …
S Bonte, S De Munter, L Billiet, G Goetgeluk… - …, 2021 - Taylor & Francis
T cell receptor (TCR)-redirected T cells target intracellular antigens such as Wilms’ tumor 1 (WT1),
a tumor-associated antigen overexpressed in several malignancies, including acute …
a tumor-associated antigen overexpressed in several malignancies, including acute …
T-cells with a single tumor antigen-specific T-cell receptor can be generated in vitro from clinically relevant stem cell sources
…, G Goetgeluk, J Ingels, M Pille, L Billiet… - …, 2020 - Taylor & Francis
Chimeric antigen receptor (CAR) T-cells have shown great promise in the treatment of B-cell
malignancies. For acute myeloid leukemia (AML), however, the optimal target surface …
malignancies. For acute myeloid leukemia (AML), however, the optimal target surface …
Single-cell profiling identifies a spectrum of human unconventional intraepithelial T lineage cells
L Billiet, L De Cock, GS Sanchez, RL Mayer… - bioRxiv, 2022 - biorxiv.org
In the human thymus, a CD10 + PD-1 + TCRαβ + differentiation pathway diverges from the
conventional single positive T cell lineages at the early double positive stage. These cells are …
conventional single positive T cell lineages at the early double positive stage. These cells are …