Throughout life, neural stem cells (NSCs) in different domains of the ventricular-subventricular
zone (V-SVZ) of the adult rodent brain generate several subtypes of interneurons that …

Understanding any brain circuit will require a categorization of its constituent neurons. In
hippocampal area CA1, at least 23 classes of GABAergic neuron have been proposed to date. …

Background Recent Genome Wide Association Studies (GWAS) have identified novel rare
coding variants in immune genes associated with late onset Alzheimer’s disease (LOAD). …

Highlights • Cortical interneurons originate in the embryonic subcortical telencephalon. • Spatial
and temporal control of progenitor differentiation generates diversity. • Genetic pathways …

The central role of the resident innate immune cells of the brain (microglia) in neurodegeneration
has become clear over the past few years largely through genome-wide association …

The transcription factor NKX2-1 is best known for its role in the specification of subsets of
cortical, striatal, and pallidal neurons. We demonstrate through genetic fate mapping and …

Interneurons navigate along multiple tangential paths to settle into appropriate cortical layers.
They undergo a saltatory migration paced by intermittent nuclear jumps whose regulation …

RNA analysis at the cellular resolution in the human brain is challenging. Here, we describe
an optimised approach for detecting single RNA transcripts in a cell-type specific manner in …

Cortical interneurons originating in the embryonic medial ganglionic eminence (MGE)
diverge into a range of different subtypes found in the adult mouse cerebral cortex. The …

Phospholipase Cε (PLCε) has been characterized as a direct effector of Ras in vitro and in
cellular systems; however, the role of PLCε in tumorigenesis and its link to Ras in this context …