User profiles for Lorenzo Mortara
lorenzo mortaradocente di immunologia e patologia generale Verified email at uninsubria.it Cited by 5661 |
CIITA-induced MHC class II expression in mammary adenocarcinoma leads to a Th1 polarization of the tumor microenvironment, tumor rejection, and specific …
L Mortara, P Castellani, R Meazza, G Tosi… - Clinical cancer …, 2006 - AACR
Purpose: We have shown previously that the MHC class II–negative murine TS/A adenocarcinoma
is rejected in vivo if induced to express MHC class II molecules by transfection of the …
is rejected in vivo if induced to express MHC class II molecules by transfection of the …
[HTML][HTML] Macrophage polarization in chronic inflammatory diseases: killers or builders?
Macrophages are key cellular components of the innate immunity, acting as the main player
in the first-line defence against the pathogens and modulating homeostatic and …
in the first-line defence against the pathogens and modulating homeostatic and …
[HTML][HTML] Contribution to tumor angiogenesis from innate immune cells within the tumor microenvironment: implications for immunotherapy
The critical role of angiogenesis in promoting tumor growth and metastasis is strongly
established. However, tumors show considerable variation in angiogenic characteristics and in …
established. However, tumors show considerable variation in angiogenic characteristics and in …
Inflammation, inflammatory cells and angiogenesis: decisions and indecisions
…, A De Lerma Barbaro, N Vannini, L Mortara… - Cancer and Metastasis …, 2008 - Springer
Endothelial-immune cell cross-talk goes well beyond leukocyte and lymphocyte trafficking,
since immune cells are able to intimately regulate vessel formation and function. Here we …
since immune cells are able to intimately regulate vessel formation and function. Here we …
The proangiogenic phenotype of natural killer cells in patients with non-small cell lung cancer
The tumor microenvironment can polarize innate immune cells to a proangiogenic phenotype.
Decidual natural killer (dNK) cells show an angiogenic phenotype, yet the role for NK …
Decidual natural killer (dNK) cells show an angiogenic phenotype, yet the role for NK …
[HTML][HTML] Myeloid derived suppressor cells interactions with natural killer cells and pro-angiogenic activities: roles in tumor progression
Myeloid-derived suppressor cells (MDSCs) contribute to the induction of an immune
suppressive/anergic, tumor permissive environment. MDSCs act as immunosuppression …
suppressive/anergic, tumor permissive environment. MDSCs act as immunosuppression …
CD56brightCD16− NK cells produce adenosine through a CD38-mediated pathway and act as regulatory cells inhibiting autologous CD4+ T cell proliferation
…, A Imperatori, S Zanellato, L Mortara… - The Journal of …, 2015 - journals.aai.org
Recent studies suggested that human CD56 bright CD16− NK cells may play a role in the
regulation of the immune response. Since the mechanism (s) involved have not yet been …
regulation of the immune response. Since the mechanism (s) involved have not yet been …
[HTML][HTML] Dendritic cell editing by activated natural killer cells results in a more protective cancer-specific immune response
Over the last decade, several studies have extensively reported that activated natural killer (NK)
cells can kill autologous immature dendritic cells (DCs) in vitro, whereas they spare fully …
cells can kill autologous immature dendritic cells (DCs) in vitro, whereas they spare fully …
[HTML][HTML] Natural killer cells as key players of tumor progression and angiogenesis: old and novel tools to divert their pro-tumor activities into potent anti-tumor effects
Immune cells, as a consequence of their plasticity, can acquire altered phenotype/functions
within the tumor microenvironment (TME). Some of these aberrant functions include …
within the tumor microenvironment (TME). Some of these aberrant functions include …
[HTML][HTML] The ovarian cancer tumor immune microenvironment (TIME) as target for therapy: a focus on innate immunity cells as therapeutic effectors
Ovarian cancer (OvCA) accounts for one of the leading causes of death from gynecologic
malignancy. Despite progress in therapy improvements in OvCA, most patients develop a …
malignancy. Despite progress in therapy improvements in OvCA, most patients develop a …