User profiles for Lotte P. Watts
 | Lotte WattsPostdoctoral Fellow, University of Colorado Boulder Verified email at colorado.edu Cited by 146 |
Rapid adaptation to CDK2 inhibition exposes intrinsic cell-cycle plasticity
CDK2 is a core cell-cycle kinase that phosphorylates many substrates to drive progression
through the cell cycle. CDK2 is hyperactivated in multiple cancers and is therefore an …
through the cell cycle. CDK2 is hyperactivated in multiple cancers and is therefore an …
Replication timing maintains the global epigenetic state in human cells
The temporal order of DNA replication [replication timing (RT)] is correlated with chromatin
modifications and three-dimensional genome architecture; however, causal links have not …
modifications and three-dimensional genome architecture; however, causal links have not …
The RIF1-long splice variant promotes G1 phase 53BP1 nuclear bodies to protect against replication stress
Human cells lacking RIF1 are highly sensitive to replication inhibitors, but the reasons for
this sensitivity have been enigmatic. Here, we show that RIF1 must be present both during …
this sensitivity have been enigmatic. Here, we show that RIF1 must be present both during …
A Highly Anticipated Selective Therapeutic Agent against CDK2: INX-315
LP Watts, SL Spencer - Cancer Discovery, 2024 - AACR
In this issue, Dietrich, Trub, and colleagues describe and characterize a novel selective
CDK2 inhibitor: INX-315. This agent shows promise in CCNE1-amplified cancers and in …
CDK2 inhibitor: INX-315. This agent shows promise in CCNE1-amplified cancers and in …
Cells rapidly adapt to cdk2 inhibitors via plasticity of the cdk2/4/6-rb-e2f axis
CDK2 is a core cell-cycle enzyme that phosphorylates a variety of substrates to drive progression
through the cell cycle. CDK2 is hyperactivated in multiple cancers and is therefore an …
through the cell cycle. CDK2 is hyperactivated in multiple cancers and is therefore an …
[PDF][PDF] RIF1-Long promotes G1 phase 53BP1 nuclear bodies to protect against replication stress
Human cells lacking RIF1 are highly sensitive to replication inhibitors, but the reasons for
this sensitivity have been enigmatic. Here we show that RIF1 must be present both during …
this sensitivity have been enigmatic. Here we show that RIF1 must be present both during …
Social relationships of immigrant and resident female mountain gorillas, II: Relatedness, residence, and relationships between females
DP Watts - American Journal of Primatology, 1994 - Wiley Online Library
… had 10-29 members and 5-12 adult and adolescent females (Table I) (adolescents were
7-9 years old-ie, post-menarcheal females younger than the average age at fertility [Watts & …
7-9 years old-ie, post-menarcheal females younger than the average age at fertility [Watts & …
Exploring the depths of on‐water training in highly‐trained rowing athletes
This investigation examined the association between on‐water rowing stroke‐rate (SR),
velocity and heart‐rate (HR) in highly trained rowers (n = 8 male; n = 8 female and 19.3 ± 1.1 …
velocity and heart‐rate (HR) in highly trained rowers (n = 8 male; n = 8 female and 19.3 ± 1.1 …
Conceptual design of the tangentially viewing combined interferometer-polarimeter for ITER density measurements
…, D Johnson, L Lin, RC O'Neill, C Watts - Review of Scientific …, 2013 - pubs.aip.org
One of the systems planned for the measurement of electron density in ITER is a multi-channel
tangentially viewing combined interferometer-polarimeter (TIP). This work discusses the …
tangentially viewing combined interferometer-polarimeter (TIP). This work discusses the …
[BOOK][B] Environment and empire
W Beinart, L Hughes - 2007 - books.google.com
… © William Beinart and Lotte Hughes 2007 The moral rights of the authors have been … The
book was written between 2002 and 2005 when Lotte Hughes worked as a Research Officer …
book was written between 2002 and 2005 when Lotte Hughes worked as a Research Officer …