[HTML][HTML] The E3 ubiquitin-protein ligase Trim31 alleviates non-alcoholic fatty liver disease by targeting Rhbdf2 in mouse hepatocytes

…, J Liu, H Wei, Y Sun, Q Yang, Q Li, D Lou… - Nature …, 2022 - nature.com
Systemic metabolic syndrome significantly increases the risk of morbidity and mortality in
patients with non-alcoholic fatty liver disease (NAFLD) and non-alcoholic steatohepatitis (NASH…

[HTML][HTML] Drug release from core-shell PVA/silk fibroin nanoparticles fabricated by one-step electrospraying

Y Cao, F Liu, Y Chen, T Yu, D Lou, Y Guo, P Li… - Scientific reports, 2017 - nature.com
Silk fibroin (SF), a FDA-approved natural protein, is renowned for its great biocompatibility,
biodegradability, and mechanical properties. SF-based nanoparticles provide new options for …

[HTML][HTML] Mulberrin confers protection against hepatic fibrosis by Trim31/Nrf2 signaling

C Ge, J Tan, D Lou, L Zhu, Z Zhong, X Dai, Y Sun… - Redox biology, 2022 - Elsevier
Mulberrin (Mul) is a key component of the traditional Chinese medicine Romulus Mori with
various biological functions. However, the effects of Mul on liver fibrosis have not been …

[HTML][HTML] iRhom2 loss alleviates renal injury in long-term PM2. 5-exposed mice by suppression of inflammation and oxidative stress

…, L Jinxiao, W Mingxing, W Sujun, M Yongjie, L Deshuai… - Redox biology, 2018 - Elsevier
Particulate matter (PM2.5) is a risk factor for organ injury and disease progression, such as
lung, brain and liver. However, its effects on renal injury and the underlying molecular …

Loss of RIP3 initiates annihilation of high-fat diet initialized nonalcoholic hepatosteatosis: A mechanism involving Toll-like receptor 4 and oxidative stress

…, L Jinxiao, W Sujun, M Yongjie, L Deshuai… - Free Radical Biology …, 2019 - Elsevier
Non-alcoholic fatty liver disease (NAFLD) is a prevalent and complex disease that confers a
high risk of severe liver disorders. Although such public and clinical health importance, very …

Comparative analysis of the gut microbiota of black bears in China using high-throughput sequencing

C Song, B Wang, J Tan, L Zhu, D Lou, X Cen - Molecular Genetics and …, 2017 - Springer
The Asiatic black bear (Ursus thibetanus) is a protected species from eastern Asia. In China,
the Asiatic black bear occurs in 17 provinces from northeast to southwest regions. To date, …

Dual drug release from core–shell nanoparticles with distinct release profiles

Y Cao, B Wang, Y Wang, D Lou - Journal of pharmaceutical sciences, 2014 - Elsevier
Multiple drug combination is a promising strategy in biomedical fields, such as cancer
chemotherapy and tissue engineering. With the aim of codelivering multiple drugs with different …

[HTML][HTML] Nrf2 mitigates prolonged PM2. 5 exposure-triggered liver inflammation by positively regulating SIKE activity: Protection by Juglanin

…, J Zhao, C Yi, L Wang, L Zhou, T Tang, Q Yang, D Lou… - Redox biology, 2020 - Elsevier
Air pollution containing particulate matter (PM) less than 2.5 μm (PM 2.5 ) plays an essential
role in regulating hepatic disease. However, its molecular mechanism is not yet clear, …

Polymer-controlled core–shell nanoparticles: a novel strategy for sequential drug release

Y Cao, B Wang, Y Wang, D Lou - RSC advances, 2014 - pubs.rsc.org
Sequentially-controlled drug release is required in cancer combination chemotherapy
treatment. With the aim of co-delivering multiple drugs with different targets, immiscible and …

Fisetin supplementation prevents high fat diet-induced diabetic nephropathy by repressing insulin resistance and RIP3-regulated inflammation

C Ge, M Xu, Y Qin, T Gu, D Lou, Q Li, L Hu, X Nie… - Food & function, 2019 - pubs.rsc.org
Obesity-related renal disease is related to caloric excess promoting deleterious cellular
responses. However, a full understanding of the molecular mechanisms involved in progressive …