Commensal bacteria are believed to have important roles in human health. The mechanisms
by which they affect mammalian physiology remain poorly understood, but bacterial …

Despite evidence linking the human microbiome to health and disease, how the microbiota
affects human physiology remains largely unknown. Microbiota-encoded metabolites are …

Background & Aims Integrated inflammatory bowel disease (IBD) care is effective but not
routinely implemented. Validated methods that simultaneously address mind and body targets …

Here we present a natural product discovery approach, whereby structures are
bioinformatically predicted from primary sequence and produced by chemical synthesis (synthetic-…

… Author links open overlay panel Louis J. Cohen 1 , Judy H. Cho 1 2 3 , Dirk Gevers 4 ,
Hiutung Chu 5 6 … https://doi.org/10.1053/j.gastro.2019.03.017…

The trillions of bacteria that make up the human microbiome are believed to encode functions
that are important to human health; however, little is known about the specific effectors that …

Bacterial culture broth extracts have been the starting point for the development of numerous
therapeutics. However, only a small fraction of bacterial biosynthetic diversity is accessible …

Objectives The role of infliximab in treating pediatric ulcerative colitis (UC) is not defined. The
authors previously have described their experience with the open label use of infliximab in …

The mechanisms by which commensal organisms affect human physiology remain poorly
understood. Lectins are non-enzymatic carbohydrate binding proteins that all organisms …

The forces that shape human microbial ecology are complex. It is likely that human microbiota,
similarly to other microbiomes, use antibiotics as one way to establish an ecological niche…