Pediatric glioblastomas (GBM) including diffuse intrinsic pontine gliomas (DIPG) are
devastating brain tumors with no effective therapy. Here, we investigated clinical and biological …

Diffuse intrinsic pontine glioma (DIPG) is a fatal brain cancer that arises in the brainstem of
children, with no effective treatment and near 100% fatality. The failure of most therapies can …

As whole-genome sequencing for cancer genome analysis becomes a clinical tool, a full
understanding of the variables affecting sequencing analysis output is required. Here using …

Background: Severe pulmonary injury with thedevelopment of ARDS is a potential
complication of cardiac surgery and cardiopulmonary bypass (CPB). Study objectives: …

We recently reported that atypical teratoid rhabdoid tumors (ATRTs) comprise at least two
transcriptional subtypes with different clinical outcomes; however, the mechanisms underlying …

Background Patients with a mediastinal mass are at risk for cardiorespiratory complications
in the perioperative period. The authors' objectives were to evaluate the incidence of life-…

The incidence of renal cell carcinoma (RCC) is increasing worldwide, and its prevalence is
particularly high in some parts of Central Europe. Here we undertake whole-genome and …

Background Rhabdoid brain tumours, also called atypical teratoid rhabdoid tumours, are
lethal childhood cancers with characteristic genetic alterations of SMARCB1/hSNF5. Lack of …

Background With the decreasing cost of sequencing and the rapid developments in genomics
technologies and protocols, the need for validated bioinformatics software that enables …

Background Accurate molecular diagnosis of monogenic non-autoimmune neonatal diabetes
mellitus (NDM) is critical for patient care, as patients carrying a mutation in KCNJ11 or …