User profiles for Louise Leyre

Louise Leyre

PhD student
Verified email at med.cornell.edu
Cited by 971

Rapid HIV RNA rebound after antiretroviral treatment interruption in persons durably suppressed in Fiebig I acute HIV infection

DJ Colby, L Trautmann, S Pinyakorn, L Leyre… - Nature medicine, 2018 - nature.com
Antiretroviral therapy during the earliest stage of acute HIV infection (Fiebig I) might minimize
establishment of a latent HIV reservoir and thereby facilitate viremic control after analytical …

Ulcerative colitis is characterized by a plasmablast-skewed humoral response associated with disease activity

…, BL Cohen, A Rahman, F Cossarini, A Seki, L Leyre… - Nature medicine, 2022 - nature.com
B cells, which are critical for intestinal homeostasis, remain understudied in ulcerative colitis
(UC). In this study, we recruited three cohorts of patients with UC (primary cohort, n = 145; …

[HTML][HTML] Single-cell characterization and quantification of translation-competent viral reservoirs in treated and untreated HIV infection

…, A Pagliuzza, R Fromentin, C Dufour, L Leyre… - PLoS …, 2019 - journals.plos.org
The phenotypic characterization of the cells in which HIV persists during antiretroviral
therapy (ART) remains technically challenging. We developed a simple flow cytometry-based …

Abundant HIV-infected cells in blood and tissues are rapidly cleared upon ART initiation during acute HIV infection

L Leyre, E Kroon, C Vandergeeten… - Science translational …, 2020 - science.org
The timing and location of the establishment of the viral reservoir during acute HIV infection
remain unclear. Using longitudinal blood and tissue samples obtained from HIV-infected …

Anti-α4β7 therapy targets lymphoid aggregates in the gastrointestinal tract of HIV-1–infected individuals

…, C Tomescu, IN SahBandar, HM Ko, L Leyre… - Science translational …, 2018 - science.org
Gut homing CD4 + T cells expressing the integrin α4β7 are early viral targets and contribute
to HIV-1 pathogenesis, likely by seeding the gastrointestinal (GI) tract with HIV. Although …

[HTML][HTML] SARS CoV-2 mRNA vaccination exposes latent HIV to Nef-specific CD8+ T-cells

EM Stevenson, S Terry, D Copertino, L Leyre… - Nature …, 2022 - nature.com
Efforts to cure HIV have focused on reactivating latent proviruses to enable elimination by
CD8 + cytotoxic T-cells. Clinical studies of latency reversing agents (LRA) in antiretroviral …

[PDF][PDF] An active HIV reservoir during ART is associated with maintenance of HIV-specific CD8+ T cell magnitude and short-lived differentiation status

…, S Buranapraditkun, C Sacdalan, L Leyre… - Cell host & …, 2023 - cell.com
Before initiation of antiretroviral therapy (ART), HIV-specific CD8 + T cells are dysfunctional
and short lived. To better understand the relationship between the HIV reservoir in CD4 + T …

Acute retroviral syndrome is associated with high viral burden, CD4 depletion, and immune activation in systemic and tissue compartments

…, A Schuetz, SJ Krebs, BM Slike, L Leyre… - Clinical Infectious …, 2018 - academic.oup.com
Background Many individuals with acute human immunodeficiency virus infection (AHI)
experience acute retroviral syndrome (ARS), which is associated with adverse long-term clinical …

[HTML][HTML] Distinct biomarker signatures in HIV acute infection associate with viral dynamics and reservoir size

JE Teigler, L Leyre, N Chomont, B Slike, N Jian… - JCI insight, 2018 - ncbi.nlm.nih.gov
Estimating the size of the viral reservoir is critical for HIV cure strategies. Biomarkers in
peripheral circulation may give insights into the establishment of the viral reservoir in …

Upregulation of IL-32 isoforms in virologically suppressed HIV-infected individuals: potential role in persistent inflammation and transcription from stable HIV-1 …

SM Zaidan, L Leyre, R Bunet… - JAIDS Journal of …, 2019 - journals.lww.com
Background: Human IL-32 is a polyfunctional cytokine that was initially reported to inhibit
HIV-1 infection. However, recent data suggest that IL-32 may enhance HIV-1 replication by …