User profiles for Louise Leyre
Louise LeyrePhD student Verified email at med.cornell.edu Cited by 971 |
Rapid HIV RNA rebound after antiretroviral treatment interruption in persons durably suppressed in Fiebig I acute HIV infection
DJ Colby, L Trautmann, S Pinyakorn, L Leyre… - Nature medicine, 2018 - nature.com
Antiretroviral therapy during the earliest stage of acute HIV infection (Fiebig I) might minimize
establishment of a latent HIV reservoir and thereby facilitate viremic control after analytical …
establishment of a latent HIV reservoir and thereby facilitate viremic control after analytical …
Ulcerative colitis is characterized by a plasmablast-skewed humoral response associated with disease activity
…, BL Cohen, A Rahman, F Cossarini, A Seki, L Leyre… - Nature medicine, 2022 - nature.com
B cells, which are critical for intestinal homeostasis, remain understudied in ulcerative colitis
(UC). In this study, we recruited three cohorts of patients with UC (primary cohort, n = 145; …
(UC). In this study, we recruited three cohorts of patients with UC (primary cohort, n = 145; …
[HTML][HTML] Single-cell characterization and quantification of translation-competent viral reservoirs in treated and untreated HIV infection
…, A Pagliuzza, R Fromentin, C Dufour, L Leyre… - PLoS …, 2019 - journals.plos.org
The phenotypic characterization of the cells in which HIV persists during antiretroviral
therapy (ART) remains technically challenging. We developed a simple flow cytometry-based …
therapy (ART) remains technically challenging. We developed a simple flow cytometry-based …
Abundant HIV-infected cells in blood and tissues are rapidly cleared upon ART initiation during acute HIV infection
L Leyre, E Kroon, C Vandergeeten… - Science translational …, 2020 - science.org
The timing and location of the establishment of the viral reservoir during acute HIV infection
remain unclear. Using longitudinal blood and tissue samples obtained from HIV-infected …
remain unclear. Using longitudinal blood and tissue samples obtained from HIV-infected …
Anti-α4β7 therapy targets lymphoid aggregates in the gastrointestinal tract of HIV-1–infected individuals
Gut homing CD4 + T cells expressing the integrin α4β7 are early viral targets and contribute
to HIV-1 pathogenesis, likely by seeding the gastrointestinal (GI) tract with HIV. Although …
to HIV-1 pathogenesis, likely by seeding the gastrointestinal (GI) tract with HIV. Although …
[HTML][HTML] SARS CoV-2 mRNA vaccination exposes latent HIV to Nef-specific CD8+ T-cells
EM Stevenson, S Terry, D Copertino, L Leyre… - Nature …, 2022 - nature.com
Efforts to cure HIV have focused on reactivating latent proviruses to enable elimination by
CD8 + cytotoxic T-cells. Clinical studies of latency reversing agents (LRA) in antiretroviral …
CD8 + cytotoxic T-cells. Clinical studies of latency reversing agents (LRA) in antiretroviral …
[PDF][PDF] An active HIV reservoir during ART is associated with maintenance of HIV-specific CD8+ T cell magnitude and short-lived differentiation status
…, S Buranapraditkun, C Sacdalan, L Leyre… - Cell host & …, 2023 - cell.com
Before initiation of antiretroviral therapy (ART), HIV-specific CD8 + T cells are dysfunctional
and short lived. To better understand the relationship between the HIV reservoir in CD4 + T …
and short lived. To better understand the relationship between the HIV reservoir in CD4 + T …
Acute retroviral syndrome is associated with high viral burden, CD4 depletion, and immune activation in systemic and tissue compartments
Background Many individuals with acute human immunodeficiency virus infection (AHI)
experience acute retroviral syndrome (ARS), which is associated with adverse long-term clinical …
experience acute retroviral syndrome (ARS), which is associated with adverse long-term clinical …
[HTML][HTML] Distinct biomarker signatures in HIV acute infection associate with viral dynamics and reservoir size
Estimating the size of the viral reservoir is critical for HIV cure strategies. Biomarkers in
peripheral circulation may give insights into the establishment of the viral reservoir in …
peripheral circulation may give insights into the establishment of the viral reservoir in …
Upregulation of IL-32 isoforms in virologically suppressed HIV-infected individuals: potential role in persistent inflammation and transcription from stable HIV-1 …
SM Zaidan, L Leyre, R Bunet… - JAIDS Journal of …, 2019 - journals.lww.com
Background: Human IL-32 is a polyfunctional cytokine that was initially reported to inhibit
HIV-1 infection. However, recent data suggest that IL-32 may enhance HIV-1 replication by …
HIV-1 infection. However, recent data suggest that IL-32 may enhance HIV-1 replication by …