Background Previous trials have shown that pridopidine might reduce motor impairment in
patients with Huntington's disease. The aim of this study was to ascertain whether higher …

Background: Latrepirdine is an orally administered experimental small molecule that was
initially developed as an antihistamine and subsequently was shown to stabilize mitochondrial …

Objective To determine the risk of all‐cause and disease‐specific mortality among older
women with hip osteoarthritis (OA) and to identify mediators in the causal pathway. Methods …

Individuals with severe, undiagnosed developmental disorders (DDs) are enriched for damaging
de novo mutations (DNMs) in developmentally important genes. We exome sequenced …

Purpose To examine the association between objectively measured physical activity and
risk of developing incident knee osteoarthritis (OA) in a community-based cohort of middle-…

Objective Knee cartilage damage is often linked to mechanical overloading. However,
cartilage requires mechanical load to remain healthy, suggesting that underloading may be …

Aims In populations of black African ancestry (BA), a paradox exists whereby lower visceral
adipose tissue is found despite their high risk for type 2 diabetes (T2D). This systematic …

Objective Adults with radiographic knee OA (rKOA) are at increased risk of mortality and
walking difficulty may modify this relation. Little is known about specific aspects of walking …

There is extensive literature reporting discordance between the presence and severity of
symptoms and the degree of radiographic structural osteoarthritis (OA). 1–5 Genetic differences …

… Marcus Nevitt argues instead that throughout the revolutionary decades pamphlet culture
was actually constructed around the public silence and exclusion of women. In support of his …