Activation of melanocortin-4-receptors (MC4Rs) reduces body fat stores by decreasing food
intake and increasing energy expenditure. MC4Rs are expressed in multiple CNS sites, any …

Failure to secrete adequate amounts of insulin in response to increasing concentrations of
glucose is an important feature of type 2 diabetes. The mechanism for loss of glucose …

Chronically elevated levels of glucose impair pancreatic beta-cell function while inducing
beta-cell proliferation. MicroRNA-29a (miR-29a) levels are increased in several tissues in …

The global epidemic of diabetes is a serious threat against health and healthcare expenses.
Although genetics is important it does not explain the dramatic increase in incidence, which …

Mitochondria are important organelles in cellular metabolism. Several crucial metabolic
pathways such as the energy producing electron transport chain or the tricarboxylic acid cycle …

… *Address all correspondence and requests for reprints to: Louise T. Dalgaard, Department
of Science and Environment, Roskilde University, Universitetsvej 1, Bldg. 28A1, DK-4000 …

Tight regulation of fatty acid metabolism in pancreatic β-cells is important for β-cell viability
and function. Chronic exposure to elevated concentrations of fatty acid is associated with β-…

Polycystic ovary syndrome (PCOS) is a frequent endocrine disorder in women. PCOS is
associated with altered features of androgen metabolism, increased insulin resistance and …

The microRNA-29 family members miR-29a-3p, miR-29b-3p, and miR-29c-3p are ubiquitously
expressed and consistently increased in various tissues and cell types in conditions of …

Background: Women with polycystic ovary syndrome (PCOS) often change their metabolic
profile over time to decrease levels of androgens while often gaining a propensity for the …