User profiles for Lu Xie

Lu Xie

Carnegie Mellon University
Verified email at andrew.cmu.edu
Cited by 1282

Gene expression elucidates functional impact of polygenic risk for schizophrenia

…, AE Cicek, KK Dang, A Browne, C Lu, L Xie… - Nature …, 2016 - nature.com
Over 100 genetic loci harbor schizophrenia-associated variants, yet how these variants
confer liability is uncertain. The CommonMind Consortium sequenced RNA from dorsolateral …

Novel biomarkers for pre‐diabetes identified by metabolomics

…, W Roemisch‐Margl, M Carstensen, L Xie… - Molecular systems …, 2012 - embopress.org
Type 2 diabetes (T2D) can be prevented in pre‐diabetic individuals with impaired glucose
tolerance (IGT). Here, we have used a metabolomics approach to identify candidate …

[HTML][HTML] Apatinib for advanced sarcoma: results from multiple institutions' off-label use in China

L Xie, W Guo, Y Wang, T Yan, T Ji, J Xu - BMC cancer, 2018 - Springer
Background Anti-angiogenesis Tyrosine kinase inhibitors (TKIs) have been proved to show
promising effects on prolonging progression-free survival (PFS) for advanced sarcoma after …

Acetylation of metabolic enzymes coordinates carbon source utilization and metabolic flux

…, Y Zhang, C Yang, H Xiong, Y Lin, J Yao, H Li, L Xie… - Science, 2010 - science.org
Lysine acetylation regulates many eukaryotic cellular processes, but its function in prokaryotes
is largely unknown. We demonstrated that central metabolism enzymes in Salmonella …

[HTML][HTML] Optical signature of symmetry variations and spin-valley coupling in atomically thin tungsten dichalcogenides

H Zeng, GB Liu, J Dai, Y Yan, B Zhu, R He, L Xie… - Scientific reports, 2013 - nature.com
We report systematic optical studies of WS 2 and WSe 2 monolayers and multilayers. The
efficiency of second harmonic generation shows a dramatic even-odd oscillation with the …

Activation of the Erk pathway is required for TGF-β1-induced EMT in vitro

L Xie, BK Law, AM Chytil, KA Brown, ME Aakre… - Neoplasia, 2004 - Elsevier
Transforming growth factor-β1 (TGF-β1) can be tumorsuppressive through the activation of
the Smadmediated signaling pathway. TGF-β1 can also enhance tumor progression by …

Proteomics identifies new therapeutic targets of early-stage hepatocellular carcinoma

…, F Tian, H Xu, J Zhou, Z Wu, T Shi, W Zhu, J Qin, L Xie… - Nature, 2019 - nature.com
Hepatocellular carcinoma is the third leading cause of deaths from cancer worldwide. Infection
with the hepatitis B virus is one of the leading risk factors for developing hepatocellular …

Diagnostic and prognostic implications of microRNAs in human hepatocellular carcinoma

W Li, L Xie, X He, J Li, K Tu, L Wei, J Wu… - … journal of cancer, 2008 - Wiley Online Library
MicroRNAs (miRNAs) are important gene regulators, which are often deregulated in cancers.
In this study, the authors analyzed the microRNAs profiles of 78 matched cancer/…

[HTML][HTML] Differences between human plasma and serum metabolite profiles

…, A Polonikov, N Dahmen, H Prokisch, L Xie… - PloS one, 2011 - journals.plos.org
Background Human plasma and serum are widely used matrices in clinical and biological
studies. However, different collecting procedures and the coagulation cascade influence …

Immunotherapy for osteosarcoma: Fundamental mechanism, rationale, and recent breakthroughs

C Chen, L Xie, T Ren, Y Huang, J Xu, W Guo - Cancer letters, 2021 - Elsevier
Osteosarcoma (OS) is the most common primary malignancy of the bone and has a high
propensity for local invasion and metastasis. Although combining surgery with chemotherapy …