Neurotrophins have diverse functions in the CNS. Initially synthesized as precursors (proneurotrophins),
they are cleaved to produce mature proteins, which promote neuronal survival …

It is widely accepted that neuronal activity plays a pivotal role in synaptic plasticity.
Neurotrophins have emerged recently as potent factors for synaptic modulation. The relationship …

Brain-derived neurotrophic factor (BDNF) modulates hippocampal plasticity and
hippocampal-dependent memory in cell models and in animals. We examined the effects of a valine …

The endocrine system dynamically controls tissue differentiation and homeostasis, but has
not been studied using dynamic tissue culture paradigms. Here we show that a microfluidic …

The 'neurotrophin hypothesis of depression' is based largely on correlations between stress
or antidepressant treatment and down- or upregulation, respectively, of brain-derived …

Despite its increasing use in experimental and clinical settings, the cellular and molecular
mechanisms underlying transcranial direct current stimulation (tDCS) remain unknown. …

Although the mutation of α-synuclein, a protein associated with presynaptic vesicles, is
implicated in the etiology and pathogenesis of Parkinson's disease, the biological function of the …

To isolate high-quality human postnatal stem cells from accessible resources is an important
goal for stem-cell research. In this study we found that exfoliated human deciduous tooth …

NEUROTROPHINS promote neuronal survival and differentiation, but the fact that their
expression is modified by neuronal activity, suggests a role in regulating synapse development …

Long-term memory is thought to be mediated by protein synthesis–dependent, late-phase
long-term potentiation (L-LTP). Two secretory proteins, tissue plasminogen activator (tPA) and …