The yin and yang of neurotrophin action
B Lu, PT Pang, NH Woo - Nature Reviews Neuroscience, 2005 - nature.com
Neurotrophins have diverse functions in the CNS. Initially synthesized as precursors (proneurotrophins),
they are cleaved to produce mature proteins, which promote neuronal survival …
they are cleaved to produce mature proteins, which promote neuronal survival …
BDNF and activity-dependent synaptic modulation
B Lu - Learning & memory, 2003 - learnmem.cshlp.org
It is widely accepted that neuronal activity plays a pivotal role in synaptic plasticity.
Neurotrophins have emerged recently as potent factors for synaptic modulation. The relationship …
Neurotrophins have emerged recently as potent factors for synaptic modulation. The relationship …
[HTML][HTML] The BDNF val66met polymorphism affects activity-dependent secretion of BDNF and human memory and hippocampal function
Brain-derived neurotrophic factor (BDNF) modulates hippocampal plasticity and
hippocampal-dependent memory in cell models and in animals. We examined the effects of a valine …
hippocampal-dependent memory in cell models and in animals. We examined the effects of a valine …
[HTML][HTML] A microfluidic culture model of the human reproductive tract and 28-day menstrual cycle
…, CA Arnold-Murray, K Chen, M Jiang, L Bai… - Nature …, 2017 - nature.com
The endocrine system dynamically controls tissue differentiation and homeostasis, but has
not been studied using dynamic tissue culture paradigms. Here we show that a microfluidic …
not been studied using dynamic tissue culture paradigms. Here we show that a microfluidic …
New insights into BDNF function in depression and anxiety
K Martinowich, H Manji, B Lu - Nature neuroscience, 2007 - nature.com
The 'neurotrophin hypothesis of depression' is based largely on correlations between stress
or antidepressant treatment and down- or upregulation, respectively, of brain-derived …
or antidepressant treatment and down- or upregulation, respectively, of brain-derived …
[PDF][PDF] Direct current stimulation promotes BDNF-dependent synaptic plasticity: potential implications for motor learning
Despite its increasing use in experimental and clinical settings, the cellular and molecular
mechanisms underlying transcranial direct current stimulation (tDCS) remain unknown. …
mechanisms underlying transcranial direct current stimulation (tDCS) remain unknown. …
Synaptic vesicle depletion correlates with attenuated synaptic responses to prolonged repetitive stimulation in mice lacking α-synuclein
…, A Chen, CE Ellis, R Paylor, B Lu… - Journal of …, 2002 - Soc Neuroscience
Although the mutation of α-synuclein, a protein associated with presynaptic vesicles, is
implicated in the etiology and pathogenesis of Parkinson's disease, the biological function of the …
implicated in the etiology and pathogenesis of Parkinson's disease, the biological function of the …
SHED: stem cells from human exfoliated deciduous teeth
M Miura, S Gronthos, M Zhao, B Lu… - Proceedings of the …, 2003 - National Acad Sciences
To isolate high-quality human postnatal stem cells from accessible resources is an important
goal for stem-cell research. In this study we found that exfoliated human deciduous tooth …
goal for stem-cell research. In this study we found that exfoliated human deciduous tooth …
Regulation of synaptic responses to high-frequency stimulation and LTP by neurotrophins in the hippocampus
A Figurov, LD Pozzo-Miller, P Olafsson, T Wang, B Lu - Nature, 1996 - nature.com
NEUROTROPHINS promote neuronal survival and differentiation, but the fact that their
expression is modified by neuronal activity, suggests a role in regulating synapse development …
expression is modified by neuronal activity, suggests a role in regulating synapse development …
Cleavage of proBDNF by tPA/plasmin is essential for long-term hippocampal plasticity
…, S Zhen, KK Teng, WH Yung, BL Hempstead, B Lu - Science, 2004 - science.org
Long-term memory is thought to be mediated by protein synthesis–dependent, late-phase
long-term potentiation (L-LTP). Two secretory proteins, tissue plasminogen activator (tPA) and …
long-term potentiation (L-LTP). Two secretory proteins, tissue plasminogen activator (tPA) and …