[HTML][HTML] Multiple membrane-cytoplasmic domain contacts in the cystic fibrosis transmembrane conductance regulator (CFTR) mediate regulation of channel gating
L He, AA Aleksandrov, AWR Serohijos… - Journal of Biological …, 2008 - ASBMB
The cystic fibrosis transmembrane conductance regulator (CFTR) is a unique ATP-binding
cassette (ABC) ion channel mutated in patients with cystic fibrosis. The most common mutation…
cassette (ABC) ion channel mutated in patients with cystic fibrosis. The most common mutation…
Regulatory insertion removal restores maturation, stability and function of ΔF508 CFTR
AA Aleksandrov, P Kota, LA Aleksandrov, L He… - Journal of molecular …, 2010 - Elsevier
The cystic fibrosis transmembrane conductance regulator (CFTR) epithelial anion channel
is a large multidomain membrane protein that matures inefficiently during biosynthesis. Its …
is a large multidomain membrane protein that matures inefficiently during biosynthesis. Its …
Membrane protein stability can be compromised by detergent interactions with the extramembranous soluble domains
…, Q Zhou, J An, E Hildebrandt, LA Aleksandrov… - Protein …, 2014 - Wiley Online Library
Detergent interaction with extramembranous soluble domains (ESDs) is not commonly
considered an important determinant of integral membrane protein (IMP) behavior during …
considered an important determinant of integral membrane protein (IMP) behavior during …
[HTML][HTML] Purification and crystallization of the cystic fibrosis transmembrane conductance regulator (CFTR)
MF Rosenberg, AB Kamis, LA Aleksandrov… - Journal of Biological …, 2004 - ASBMB
The cystic fibrosis transmembrane conductance regulator (CFTR) is a membrane protein that
is mutated in patients suffering from cystic fibrosis. Here we report the purification and first …
is mutated in patients suffering from cystic fibrosis. Here we report the purification and first …
Allosteric modulation balances thermodynamic stability and restores function of ΔF508 CFTR
AA Aleksandrov, P Kota, L Cui, T Jensen… - Journal of molecular …, 2012 - Elsevier
Most cystic fibrosis is caused by a deletion of a single residue (F508) in CFTR (cystic
fibrosis transmembrane conductance regulator) that disrupts the folding and biosynthetic …
fibrosis transmembrane conductance regulator) that disrupts the folding and biosynthetic …
[HTML][HTML] Restoration of domain folding and interdomain assembly by second-site suppressors of the ΔF508 mutation in CFTR
L He, LA Aleksandrov, L Cui, TJ Jensen… - The FASEB …, 2010 - ncbi.nlm.nih.gov
Deletion of PHE508 (ΔF508) from the first nucleotide-binding domain (NBD1) of CFTR, which
causes most cystic fibrosis, disrupts the folding and assembly of the protein. Although the …
causes most cystic fibrosis, disrupts the folding and assembly of the protein. Although the …
Cryo-EM visualization of an active high open probability CFTR anion channel
JF Fay, LA Aleksandrov, TJ Jensen, LL Cui… - Biochemistry, 2018 - ACS Publications
The cystic fibrosis transmembrane conductance regulator (CFTR) anion channel, crucial to
epithelial salt and water homeostasis, and defective due to mutations in its gene in patients …
epithelial salt and water homeostasis, and defective due to mutations in its gene in patients …
[HTML][HTML] CFTR (ABCC7) is a hydrolyzable-ligand-gated channel
AA Aleksandrov, LA Aleksandrov… - Pflügers Archiv-European …, 2007 - Springer
As the product of the gene mutated in cystic fibrosis, the most common genetic disease of
Caucasians, CFTR is an atypical ABC protein. From an evolutionary perspective, it is …
Caucasians, CFTR is an atypical ABC protein. From an evolutionary perspective, it is …
[HTML][HTML] The cystic fibrosis transmembrane conductance regulator (CFTR): three-dimensional structure and localization of a channel gate
…, LP O'Ryan, G Hughes, Z Zhao, LA Aleksandrov… - Journal of Biological …, 2011 - ASBMB
Cystic fibrosis affects about 1 in 2500 live births and involves loss of transmembrane chloride
flux due to a lack of a membrane protein channel termed the cystic fibrosis transmembrane …
flux due to a lack of a membrane protein channel termed the cystic fibrosis transmembrane …
The cubicon method for concentrating membrane proteins in the cubic mesophase
P Ma, D Weichert, LA Aleksandrov, TJ Jensen… - nature protocols, 2017 - nature.com
The lipid cubic phase (in meso) method is an important approach for generating crystals
and high-resolution X-ray structures of integral membrane proteins. However, as a …
and high-resolution X-ray structures of integral membrane proteins. However, as a …