It is now becoming evident that the liver has an important role in the control of whole body
metabolism of energy nutrients. In this review, we focus on recent findings showing that AMP‐…

Metformin is currently the first-line drug treatment for type 2 diabetes. Besides its glucose-lowering
effect, there is interest in actions of the drug of potential relevance to cardiovascular …

Background: The role of protein phosphorylation in the Pasteur effect—the phenomenon
whereby anaerobic conditions stimulate glycolysis—has not been addressed. The AMP-…

Protein synthesis, in particular peptide-chain elongation, consumes cellular energy. Anoxia
activates AMP-activated protein kinase (AMPK, see [1]), resulting in the inhibition of …

The main role of insulin in the heart under physiological conditions is obviously the regulation
of substrate utilization. Indeed, insulin promotes glucose uptake and its utilization via …

Heart failure is a progressive muscular disorder leading to a deterioration of the heart
characterized by a contractile dysfunction and a chronic energy deficit. As a consequence, the …

AMP-activated protein kinase (AMPK) has been shown to inhibit cardiac hypertrophy. Here,
we show that submaximal AMPK activation blocks cardiomyocyte hypertrophy without …

Fru-2,6-P 2 (fructose 2,6-bisphosphate) is a signal molecule that controls glycolysis. Since its
discovery more than 20 years ago, inroads have been made towards the understanding of …

The activation of monocytes involves a stimulation of glycolysis, release of potent inflammatory
mediators, and alterations in gene expression. All of these processes are known to be …

AMP-activated protein kinase (AMPK), a phylogenetically conserved serine/threonine protein
kinase, has been proposed to function as a ‘fuel gauge’to monitor cellular energy status in …