High-throughput oncogene mutation profiling in human cancer
…, JC Lee, R Nicoletti, C Hatton, M Goyette, L Girard… - Nature …, 2007 - nature.com
Systematic efforts are underway to decipher the genetic changes associated with tumor
initiation and progression 1 , 2 . However, widespread clinical application of this information is …
initiation and progression 1 , 2 . However, widespread clinical application of this information is …
An epithelial–mesenchymal transition gene signature predicts resistance to EGFR and PI3K inhibitors and identifies Axl as a therapeutic target for overcoming EGFR …
Purpose: Epithelial–mesenchymal transition (EMT) has been associated with metastatic
spread and EGF receptor (EGFR) inhibitor resistance. We developed and validated a robust 76-…
spread and EGF receptor (EGFR) inhibitor resistance. We developed and validated a robust 76-…
[HTML][HTML] Molecular profiling of breast cancer cell lines defines relevant tumor models and provides a resource for cancer gene discovery
Background Breast cancer cell lines have been used widely to investigate breast cancer
pathobiology and new therapies. Breast cancer is a molecularly heterogeneous disease, and it …
pathobiology and new therapies. Breast cancer is a molecularly heterogeneous disease, and it …
Co-occurring Genomic Alterations Define Major Subsets of KRAS-Mutant Lung Adenocarcinoma with Distinct Biology, Immune Profiles, and Therapeutic …
The molecular underpinnings that drive the heterogeneity of KRAS-mutant lung
adenocarcinoma are poorly characterized. We performed an integrative analysis of genomic, …
adenocarcinoma are poorly characterized. We performed an integrative analysis of genomic, …
An integrated view of copy number and allelic alterations in the cancer genome using single nucleotide polymorphism arrays
Abstract Changes in DNA copy number contribute to cancer pathogenesis. We now show
that high-density single nucleotide polymorphism (SNP) arrays can detect copy number …
that high-density single nucleotide polymorphism (SNP) arrays can detect copy number …
Immortalization of human bronchial epithelial cells in the absence of viral oncoproteins
RD Ramirez, S Sheridan, L Girard, M Sato, Y Kim… - Cancer research, 2004 - AACR
By expressing two genes (hTERT and Cdk4), we have developed a method to reproducibly
generate continuously replicating human bronchial epithelial cell (HBEC) lines that provide a …
generate continuously replicating human bronchial epithelial cell (HBEC) lines that provide a …
PTEN Loss Contributes to Erlotinib Resistance in EGFR-Mutant Lung Cancer by Activation of Akt and EGFR
…, P Frommolt, K Michel, M Peifer, C Mermel, L Girard… - Cancer research, 2009 - AACR
Clinical resistance to epidermal growth factor receptor (EGFR) inhibition in lung cancer has
been linked to the emergence of the EGFR T790M resistance mutation or amplification of …
been linked to the emergence of the EGFR T790M resistance mutation or amplification of …
Distinct Epidermal Growth Factor Receptor and KRAS Mutation Patterns in Non–Small Cell Lung Cancer Patients with Different Tobacco Exposure and …
…, MCM Wong, KK Ho, WK Lam, SW Chiu, L Girard… - Clinical Cancer …, 2006 - AACR
Purpose: This study evaluated the mutational profile of epidermal growth factor receptor (EGFR)
and KRAS in non–small cell lung cancers in Hong Kong and determined their relation …
and KRAS in non–small cell lung cancers in Hong Kong and determined their relation …
Activating Mutations of the Noonan Syndrome-Associated SHP2/PTPN11 Gene in Human Solid Tumors and Adult Acute Myelogenous Leukemia
…, DJ Sugarbaker, WG Richards, J Du, L Girard… - Cancer research, 2004 - AACR
The SH2 domain-containing protein-tyrosine phosphatase PTPN11 (Shp2) is required for
normal development and is an essential component of signaling pathways initiated by growth …
normal development and is an essential component of signaling pathways initiated by growth …
Restoring E-cadherin expression increases sensitivity to epidermal growth factor receptor inhibitors in lung cancer cell lines
…, Z Chan, A Baron, W Franklin, HA Drabkin, L Girard… - Cancer research, 2006 - AACR
The epidermal growth factor receptor (EGFR) is overexpressed in the majority of non–small
cell lung cancers (NSCLC). EGFR tyrosine kinase inhibitors, such as gefitinib and erlotinib, …
cell lung cancers (NSCLC). EGFR tyrosine kinase inhibitors, such as gefitinib and erlotinib, …