Fertilization is defined as the process of union of two gametes, eggs and sperm. When
mammalian eggs and sperm come into contact in the female oviduct, a series of steps is set in …

Many eukaryotic extracellular proteins share a sequence of unknown function, called the zona
pellucida (ZP) domain 1 . Among these proteins are the mammalian sperm receptors ZP2 …

▪ Abstract Many eukaryotic proteins share a sequence designated as the zona pellucida (ZP)
domain. This structural element, present in extracellular proteins from a wide variety of …

The signal recognition particle (SRP) is a ribonucleoprotein particle essential for the targeting
of signal peptide-bearing proteins to the prokaryotic plasma membrane or the eukaryotic …

Many secreted eukaryotic glycoproteins that play fundamental roles in development, hearing,
immunity, and cancer polymerize into filaments and extracellular matrices through zona …

ZP3, a major component of the zona pellucida (ZP) matrix coating mammalian eggs, is
essential for fertilization by acting as sperm receptor. By retaining a propeptide that contains a …

We have re-determined the crystal structure of yeast tRNA Phe to 2.0 Å resolution using 15
year old crystals. The accuracy of the new structure, due both to higher resolution data and …

Species-specific recognition between the egg extracellular matrix (zona pellucida) and sperm
is the first, crucial step of mammalian fertilization 1 . Zona pellucida filament components …

Endoglin (ENG)/CD105 is an essential endothelial cell co-receptor of the transforming
growth factor β (TGF-β) superfamily, mutated in hereditary hemorrhagic telangiectasia type 1 (…

10.7554/eLife.08887.001 Uromodulin is the most abundant protein in the urine. It is exclusively
produced by renal epithelial cells and it plays key roles in kidney function and disease. …