Recent findings in human samples and animal models support the involvement of
inflammation in the development of Parkinson’s disease. Nevertheless, it is currently unknown …

Direct cell reprogramming enables direct conversion of fibroblasts into functional neurons
and oligodendrocytes using a minimal set of cell-lineage-specific transcription factors. This …

Dysfunctions in mitochondrial dynamics and metabolism are common pathological processes
associated with Parkinson's disease (PD). It was recently shown that an inherited form of …

Transplantation of GABAergic interneurons (INs) can provide long-term functional benefits
in animal models of epilepsy and other neurological disorders. Whereas GABAergic INs can …

Dravet syndrome (DS) is a severe epileptic encephalopathy caused mainly by heterozygous
loss-of-function mutations of the SCN1A gene, indicating haploinsufficiency as the …

P23H is the most common mutation in the RHODOPSIN (RHO) gene leading to a dominant
form of retinitis pigmentosa (RP), a rod photoreceptor degeneration that invariably causes …

Mutations in one SETD5 allele are genetic causes of intellectual disability and autistic spectrum
disorders. However, the mechanisms by which SETD5 regulates brain development and …

Dravet syndrome is a severe epileptic encephalopathy caused primarily by haploinsufficiency
of the SCN1A gene. Repetitive seizures can lead to endurable and untreatable …

High-throughput genomic, transcriptomic, and proteomic profiling reveals various mechanisms
by which multiple tumor types acquire resistance to the third-generation ALK inhibitor …

Inflammatory bowel disease (IBD) is a class of chronic disorders whose etiogenesis is still
unknown. Despite the high number of IBD-related omics studies, the RNA-sequencing data …