Single-cell RNA sequencing (scRNA-seq) is the leading technique for characterizing the
transcriptomes of individual cells in a sample. The latest protocols are scalable to thousands of …

Single-cell RNA sequencing (scRNA-seq) has emerged as a central genome-wide method
to characterize cellular identities and processes. Consequently, improving its sensitivity, …

DNA methylation (5-methylcytosine (5mC)) is critical for genome stability and transcriptional
regulation in mammals. The discovery that ten-eleven translocation (TET) proteins catalyze …

Cost-efficient library generation by early barcoding has been central in propelling single-cell
RNA sequencing. Here, we optimize and validate prime-seq, an early barcoding bulk RNA-…

Epstein-Barr virus (EBV) is a human tumor virus which preferentially infects resting human B
cells. Upon infection in vitro, EBV activates and immortalizes these cells. The viral latent …

Chemotherapy resistance is the main impediment in the treatment of acute myeloid
leukaemia (AML). Despite rapid advances, the various mechanisms inducing resistance …

Comparing the molecular and cellular properties among primates is crucial to better understand
human evolution and biology. However, it is difficult or ethically impossible to collect …

The antiviral immune response to SARS-CoV-2 infection can limit viral spread and prevent
development of pneumonic COVID-19. However, the protective immunological response …

Legumes establish endosymbiotic associations with nitrogen-fixing rhizobia, which they host
inside root nodules. Here, specific physiological and morphological adaptations, such as …

Single-cell RNA sequencing (scRNA-seq) has emerged as the central genome-wide
method to characterize cellular identities and processes. While performance of scRNA-seq …