Human induced pluripotent stem cells (hiPSCs) hold promise for myocardial repair following
injury, but preclinical studies in large animal models are required to determine optimal cell …

In embryonic development, the pancreas and liver share developmental history up to the
stage of bud formation. Therefore, we postulated that direct reprogramming of liver to …

Pdx1 (pancreatic and duodenal homeobox 1), Ngn3 (neurogenin 3) and MafA (v-maf
musculoaponeurotic fibrosarcoma oncogene family, protein A) have been reported to bring about …

The CRISPR system is widely used in genome editing for biomedical research. Here, using
either dual paired Cas9 D10A nickases or paired Cas9 nuclease we characterize …

The induced pluripotent stem cell (iPSC) technology enables derivation of patient-specific
pluripotent stem cells from adult somatic cells without using an embryonic cell source. …

Perhaps one of the most significant achievements in modern science is the discovery of
human induced pluripotent stem cells (hiPSCs), which have paved the way for regeneration …

The transcription factor RUNX1 is a critical regulator of developmental hematopoiesis and is
frequently disrupted in leukemia. Runx1 is a large, complex gene that is expressed from two …

The activation of endogenous Oct4 transcription is a key step in the reprogramming of somatic
cells into induced pluripotent stem (iPS) cells but until now it has been difficult to analyze …

With the long-term aim of developing a new type of therapy for diabetes, we have investigated
the reprogramming of liver cells in normal mice toward a pancreatic phenotype using the …

Extra-embryonic mesoderm (ExM)—composed of the earliest cells that traverse the primitive
streak—gives rise to the endothelium as well as haematopoietic progenitors in the …